Table 1—

Longitudinal changes of biochemical variables

Time point/statistic1,5AG (μg/ml)HbA1c (%)Fructosamine (μmol/l)Glucose (mg/dl)
Baseline
    Mean ± SD1.9 ± 1.99.5 ± 1.7410.6 ± 108.6225.0 ± 105.6
    Median1.49.1375.0218.0
    Minimum to maximum0.0–10.77.0–14.2269.0–908.064.0–574.0
Week 2**
    Mean ± SD3.0 ± 2.29.1 ± 1.5362.4 ± 76.5187.4 ± 91.0
    Median2.78.7348.5190.0
    Minimum to maximum0.0–12.66.8–14.0232.0–572.027.0–448.0
    Mean percent change vs. baseline57.94.211.716.7
    Median percent change vs. baseline92.94.47.112.8
Week 4
    Mean ± SD3.7 ± 2.58.8 ± 1.4340.0 ± 79.1181.4 ± 102.4
    Median3.58.7321.0157.0
    Minimum to maximum0.0–13.36.6–13.2206.0–559.029.0–701.0
    Mean percent change vs. baseline94.77.417.219.4
    Median percent change vs. baseline150.04.414.428.0
Week 8
    Mean ± SD5.0 ± 3.68.2 ± 1.2317.5 ± 75.4172.6 ± 100.5
    Median4.88.0295.0141.0
    Minimum to maximum0.0–15.76.3–12.3197.0–575.016.0–545.0
    Mean percent change vs. baseline163.213.722.723.3
    Median percent change vs. baseline242.912.121.335.3
  • Reference ranges: 1,5AG, 10.7–32.0 μg/ml (men) and 6.8–29.3 μg/ml (women); HbA1c, <6.0%; fructosamine, 205–285 μmol/l; glucose, 55–115 mg/dl.

  • *

    * One male patient did not provide a blood sample at week 2, thus the n for this time point is 76.

  • P < 0.05 vs. baseline.