Table 1—

Clinical characteristics of the study population

Normal weight (BMI <25 kg/m2)Overweight (BMI 25–29.9 kg/m2)Obese (BMI ≥30 kg/m2)P*
n208168109
Age (years)46.0 ± 13.651 ± 12.649.2 ± 12.10.001
Sex (M/F)89/11988/8048/61NS
BMI (kg/m2)22.4 ± 1.827.1 ± 1.432.8 ± 2.5<0.001
SSPG (mmol/l)5.9 ± 2.99.0 ± 4.211.8 ± 4.1<0.001
Fasting glucose (mmol/l)4.8 ± 0.65.1 ± 0.65.4 ± 0.6<0.001
Fasting insulin (pmol/l)58.3 ± 26.680.2 ± 37.4125.5 ± 66.6<0.001
HOMA-IR1.82 ± 0.902.66 ± 1.394.42 ± 2.57<0.001
QUICKI0.36 ± 0.030.34 ± 0.030.32 ± 0.02<0.001
I-AUC (pmol · l−1 · 3 h−1)864.6 ± 464.41,254.3 ± 838.91,853.9 ± 1,278.2<0.001
  • Data are means ± SD.

  • *

    * P values reflect differences between the three groups and are assessed by one-way ANOVA

  • P value = 0.001 for comparison between normal-weight versus overweight groups

  • P value <0.001 for comparison between normal weight versus overweight, normal weight versus obese, and overweight versus obese.