Table 1—

Clinical characteristics of subjects in relation to glucose tolerance

NGTIFGIGTIFG/IGTType 2 diabetes
n (men/women)216 (134/82)31 (22/9)46 (33/13)29 (25/4)146 (120/25)
Age (years)50.3 ± 15.251.3 ± 15.160.6 ± 10.9*62.9 ± 9.7*61.6 ± 10.6*
BMI (kg/m2)25.8 ± 3.927.2 ± 3.727.2 ± 3.527.8 ± 3.927.9 ± 4.5
Lean body mass (kg)57.2 ± 9.959.8 ± 11.259.5 ± 9.761.9 ± 9.561.6 ± 9.6
Waist-to-hip ratio (men)*0.95 ± 0.060.96 ± 0.050.96 ± 0.040.98 ± 0.050.987 ± 0.05
Waist-to-hip ratio (women)0.84 ± 0.060.85 ± 0.070.84 ± 0.040.85 ± 0.030.86 ± 0.05
Fasting plasma glucose (mmol/l)5.37 ± 0.46.4 ± 0.25.5 ± 0.46.4 ± 0.29.8 ± 3.5
2-h glucose (mmol/l)5.93 ± 1.16.34 ± 1.18.8 ± 0.79.2 ± 0.915.2 ± 4.9*
HbA1c (%)5.4 ± 0.55.36 ± 0.55.58 ± 0.65.86 ± 0.67.4 ± 1.9*
M value (mg · ffmkg−1 · min−1)§8.41 ± 3.37.76 ± 3.36.82 ± 2.65.86 ± 2.4*5.33 ± 2.4*
lnHOMA-IR§0.49 ± 0.50.87 ± 0.40.86 ± 0.51.18 ± 0.61.52 ± 0.7*
Si from OGTT§7.0 ± 3.94.6 ± 1.64.39 ± 2.053.9 ± 2.14.09 ± 2.7
EGP (mg · kg FFM−1 · min−1) (n)2.74 ± 0.4 (54)2.73 ± 0.3 (30)3.28 ± 0.9 (59)
Hepatic insulin sensitivity (mg · kg FFM−1 · min−1 · mUl−1)0.87 ± 0.90.73 ± 0.70.50 ± 0.35
  • Data are means ± SD.

  • *

    * P < 0.05 vs. IFG;

  • P < 0.05 vs. NGT;

  • P < 0.05 vs. IFG/IGT.

  • §

    § Values adjusted for difference in age, BMI, and sex. FFM, fat-free mass.