Characteristics of 49 children with diabetes during acute D+HUS reported in the literature, 1966 to present
| Characteristic | Median or no. with characteristic (range) | Percent with characteristic |
|---|---|---|
| Age (years) | 2.5 (1.5–9) | — |
| Female | 15 of 24 | 63 |
| Diarrhea | 40 of 40 | 100 |
| Bloody diarrhea | 12 of 13 | 92 |
| Ketoacidosis | 7 of 11 | 64 |
| CNS symptoms | 21 of 25 | 84 |
| Acute dialysis | 31 of 31 | 100 |
| Peritoneal dialysis | 21 of 27 | 78 |
| Diazoxide | 3 of 19 | 16 |
| Steroids | 0 of 14 | 0 |
| Insulin | 38 of 44 | 86 |
| Death | 10 of 44 | 23 |
| Follow-up (months) | 12 (2–180) | — |
| Persistent diabetes requiring insulin* | 11 of 34 | 32 |
| Relapse after initial recovery* | 2 of 34 | 6 |
| Complete recovery* | 21 of 34 | 62 |
| ESRD* | 4 of 19 | 21 |
| Other renal sequelae* | 6 of 13 | 46 |
| Exocrine pancreatic disease† | 7 of 20 | 35 |
↵* In survivors.
↵† Defined as increased amylase or lipase, absent fecal chymotrypsin with increased fecal fat and pancreatic calcifications, and need for pancreatic enzyme replacement. CNS, central nervous system; ESRD, end-stage renal disease requiring permanent renal replacement therapy (see text for details).