Table 1—

GGT, ALT, and cardiovascular and metabolic risk factors and inflammatory markers in older British men

GGT (IU/l)Quarters
P value (trend across groups)
1 (low) (<18)2 (19–25.9)3 (26–36.9)4 (high) (≥37)
Mean age69.268.868.568.1<0.0001
Mean waist circumference (cm)94969898<0.0001
Mean BMI25.526.627.227.3<0.0001
Percent current smokers13.212.613.313.30.84
Percent inactive31.730.334.734.30.09
Percent heavy drinkers1.32.23.37.2<0.0001
Percent manual social class54.449.854.955.80.20
Percent myocardial infarction17.316.719.220.10.07
Percent stroke3.84.15.46.50.005
Percent use of statins5.95.17.98.50.005
Metabolic and inflammatory markers
    Mean systolic blood pressure (mmHg)1471461481510.0003
    Mean HDL cholesterol (mmol/l)1.361.331.321.330.08
    Mean triglycerides (mmol/l)1.351.521.671.86<0.0001
    Mean glucose (mmol/l)5.535.535.585.580.0005
    Mean HOMA-IR0.480.660.780.78<0.0001
    Mean CRP (mg/l)1.221.541.882.20<0.0001
    Mean white cell count (109/l)6.556.756.897.03<0.0001
    Percent metabolic syndrome17.424.632.837.6<0.0001
ALT (IU/l)1 (<12)2 (13–15.9)3 (16–20.9)4 (≥ 21)P value (trend across groups)
Mean age70.768.967.766.8<0.0001
Mean waist circumference94969799<0.0001
Mean BMI25.626.527.027.7<0.0001
Percent current smokers17.913.110.79.3<0.0001
Percent inactive38.030.031.929.50.0003
Percent heavy drinkers2.72.73.94.70.009
Percent manual social class55.555.652.350.90.02
Percent myocardial infarction21.117.916.417.00.01
Percent stroke6.34.84.24.00.01
Percen use of statins6.16.38.46.90.23
Metabolic and inflammatory markers
    Mean systolic blood pressure (mmHg)1491471471490.67
    Mean HDL cholesterol (mmol/l)1.361.351.341.28<0.0001
    Mean triglycerides (mmol/l)1.401.521.631.84<0.0001
    Mean glucose (mmol/l)5.535.535.535.580.002
    Mean HOMA-IR0.500.610.710.91<0.0001
    Mean CRP (mg/l)1.901.631.511.600.0004
    Mean white cell count (109/l)6.966.696.897.030.02
    Percent metabolic syndrome20.126.727.239.4<0.0001