Table 2—

Mean number of confirmed* hypoglycemic events per patient-years

Type of hypoglycemiaInsulin glargine plus OADsPremixed insulinP
All4.079.87<0.0001
Symptomatic2.625.730.0009
Nocturnal0.511.040.0449
Severe0.000.050.0702
  • *

    * Hypoglycemia was confirmed by blood glucose <60 mg/dl (3.3 mmol/l).

  • Severe hypoglycemia was defined as symptoms consistent with hypoglycemia that required the assistance of another person and were associated with either a blood glucose level <36 mg/dl (<2.0 mmol/l) or prompt recovery after oral carbohydrate or intravenous glucose or glucagon.