Table 2—

Effect of candesartan 16 mg once daily and lisinopril 20 mg daily compared with 40 mg lisinopril on ambulatory blood pressure and renal function in 75 hypertensive patients with diabetes

Dual blockade
Lisinopril 40 mg
P value
Baseline12 monthsBaseline12 months
n38303730
Systolic ABP (mmHg)
    24 h129 ± 12123 ± 13130 ± 11128 ± 140.16
    Day134 ± 12127 ± 13135 ± 10133 ± 140.07
    Night120 ± 15114 ± 14120 ± 13117 ± 150.40
    Night/day blood pressure ratio (%)90 ± 790 ± 790 ± 787 ± 70.18
Diastolic ABP (mmHg)
    24 h75 ± 873 ± 776 ± 774 ± 80.42
    Day79 ± 877 ± 880 ± 778 ± 90.55
    Night68 ± 965 ± 967 ± 964 ± 80.51
    Night/day blood prssure ratio86 ± 986 ± 183 ± 783 ± 70.83
Serum creatinine (μmol/l)84 ± 1386 ± 1584 ± 1589 ± 170.66
Serum potassium (mmol/l)4.1 ± 0.44.2 ± 0.44.2 ± 0.44.2 ± 0.50.42
Creatinine clearance (ml/min)111 ± 30114 ± 32110 ± 50119 ± 300.65
HbA1c (%)8.2 ± 1.38.0 ± 1.68.4 ± 1.38.6 ± 1.70.59
  • Data are means ±SD. ABP, ambulatory blood pressure.