Table 3—

Mortality and hospitalizations

Metformin (n = 7,227)Usual care (n = 1,505)P
All-cause mortality
    All patients (n = 7,227)1.1 (0.9–1.4)1.3 (0.8–2.0)0.596
    Patients <65 years (n = 5,645)0.4 (0.3–0.7)0.7 (0.3–1.5)0.21
    Patients ≥65 years (n = 3,084)2.4 (1.8–3.1)2.1 (1.1–3.7)0.878
Mortality from lactic acidosis*
    All patients (n = 7,227)0 (0.00–0.05)0 (0.00–0.24)
All-cause hospitalizations
    All patients (n = 7,227)9.4 (8.8–10.1)10.4 (8.9–12.1)0.229
    Patients <65 years (n = 5,645)7.3 (6.6–8.1)7.4 (5.8–9.3)0.945
    Patients ≥65 years (n = 3,084)13.3 (12.0–14.7)15.5 (12.6–18.7)0.178
Hospitalizations for lactic acidosis*
    All patients (n = 7,227)0 (0.00–0.05)0 (0.00–0.24)
Hospitalizations for other metabolic causes
    All patients (n = 7,227)0.9 (0.7–1.2)0.9 (0.5–1.6)1.000
    Patients <65 years (n = 5,645)0.7 (0.5–1.0)0.7 (0.3–1.5)0.835
    Patients ≥65 years (n = 3,084)1.3 (0.9–1.8)1.2 (0.5–2.5)1.000
  • Data are percent of patients (95% CI).

  • *

    * Data on mortality or hospitalizations due to lactic acidosis are given for all patients only, as no events due to lactic acidosis were reported. Information on age was not captured for three patients (two in the metformin group and one in the usual care group); data for these patients are included in the ‘All patients’ section but not in the sections stratified for age at baseline. For numbers of patients aged <65 years or ≥65 years, see Table 2.