Table 3

HRs (95% CIs) of CHD according to different levels of BMI at baseline among various subpopulationsa

BMI (kg/m2)P for trendP for interaction
<25.025.0–29.930–34.935–39.9≥40
Men
 Age groups (years)>0.50
  <501.001.07 (0.86–1.33)1.19 (0.96–1.48)1.47 (1.19–1.85)1.44 (1.15–1.80)<0.001
  50–591.001.28 (1.01–1.60)1.48 (1.17–0.85)1.57 (1.23–2.00)1.56 (1.22–2.01)<0.001
  ≥601.001.01 (0.8–1.27)1.07 (0.84–1.35)1.42 (1.10–1.85)0.83 (0.59–1.15)0.38
 Race>0.10
  African American1.001.18 (0.99–1.40)1.26 (1.05–1.51)1.54 (1.26–1.88)1.53 (1.24–1.89)<0.001
  White1.001.08 (0.89–1.32)1.27 (1.05–1.54)1.54 (1.26–1.88)1.35 (1.10–1.66)<0.001
 Smoking status<0.05
  Never1.001.17 (0.95–1.44)1.35 (1.10–1.67)1.68 (1.35–2.09)1.70 (1.36–2.12)<0.001
  Ever or current1.001.33 (1.09–1.62)1.41 (1.15–1.73)1.61 (1.28–2.03)1.38 (1.08–1.76)<0.001
 Glucose-lowering medication>0.25
  No use1.001.56 (1.19–2.06)1.40 (1.05–1.88)1.66 (1.20–2.29)1.85 (1.33–2.56)0.001
  Oral hypoglycemic agents1.001.25 (0.95–1.65)1.46 (1.11–1.92)1.66 (1.23–2.23)1.57 (1.15–2.14)<0.001
   Metformin1.001.08 (0.87–1.34)1.31 (1.06–1.62)1.56 (1.24–1.95)1.47 (1.16–1.85)<0.001
   Sulfonylureas1.001.04 (0.83–1.32)1.24 (0.98–1.56)1.47 (1.15–1.88)1.32 (1.02–1.71)<0.001
   Other oral agents1.001.13 (0.78–1.66)1.35 (0.93–1.95)1.52 (1.03–2.22)1.76 (1.20–2.59)<0.001
  Insulin1.001.09 (0.88–1.34)1.29 (1.05–1.58)1.56 (1.26–1.94)1.49 (1.19–1.86)<0.001
Women
 Age groups (years)>0.05
  <501.001.10 (0.89–1.37)1.04 (0.84–1.29)1.09 (0.88–1.35)1.06 (0.86–1.30)0.70
  50–591.000.89 (0.73–1.08)0.88 (0.73–1.07)1.02 (0.84–1.24)1.06 (0.87–1.28)0.048
  ≥601.000.89 (0.72–1.09)0.89 (0.73–1.09)0.99 (0.79–1.23)1.06 (0.85–1.33)0.46
 Race>0.20
  African American1.000.90 (0.77–1.05)0.85 (0.72–0.99)1.06 (0.90–1.24)1.07 (0.92–1.26)0.005
  White1.001.03 (0.86–1.23)1.09 (0.91–1.30)1.08 (0.90–1.29)1.13 (0.95–1.35)0.17
 Smoking status>0.75
  Never1.000.92 (0.77–1.08)0.96 (0.82–1.13)1.06 (0.90–1.26)1.11 (0.94–1.31)0.005
  Ever or current1.001.05 (0.85–1.29)1.04 (0.85–1.28)1.11 (0.89–1.37)1.10 (0.89–1.37)0.21
 Glucose-lowering medication>0.05
  No use1.001.05 (0.82–1.34)1.08 (0.84–1.38)1.08 (0.83–1.40)1.30 (1.01–1.67)0.029
  Oral hypoglycemic agents1.000.94 (0.75–1.17)0.87 (0.70–1.08)0.93 (0.74–1.16)0.89 (0.71–1.12)0.43
   Metformin1.001.04 (0.86–1.26)1.04 (0.86–1.26)1.16 (0.95–1.40)1.12 (0.93–1.36)0.073
   Sulfonylureas1.000.85 (0.69–1.05)0.92 (0.75–1.12)0.99 (0.80–1.22)0.99 (0.81–1.22)0.17
   Other oral agents1.000.79 (0.60–1.03)0.77 (0.59–0.99)0.83 (0.64–1.09)0.83 (0.64–1.07)0.80
  Insulin1.000.90 (0.74–1.10)0.97 (0.80–1.18)1.12 (0.92–1.36)1.14 (0.94–1.38)0.001
  • aAdjusted for age, race, types of insurance, income, and smoking, other than the variable for stratification.