Table 4

HRs (95% CIs) of CHD according to different levels of BMI during follow-up and at last visit among various subpopulationsa

BMI (kg/m2)P for trendP for interaction
<25.025.0–29.930–34.935–39.9≥40
Follow-up
 Men
  Age groups (years)>0.25
   <501.001.07 (0.86–1.34)1.21 (0.97–1.51)1.43 (1.13–1.81)1.58 (1.25–2.00)<0.001
   50–591.001.21 (0.90–1.52)1.36 (1.08–1.71)1.59 (1.25–2.02)1.52 (1.18–1.95)<0.001
   ≥601.001.12 (0.89–1.41)1.10 (0.86–1.39)1.34 (1.02–1.77)1.07 (0.76–1.49)0.22
  Race>0.10
   African American1.001.08 (0.91–1.29)1.14 (0.95–1.36)1.50 (1.23–1.82)1.62 (1.31–2.01)<0.001
   White1.001.25 (1.03–1.53)1.41 (1.16–1.72)1.62 (1.31–1.99)1.56 (1.26–1.94)<0.001
  Smoking status<0.05
   Never1.001.23 (0.99–1.53)1.40 (1.12–1.73)1.73 (1.38–2.17)1.93 (1.53–2.43)<0.001
   Ever or current1.001.27 (1.04–1.55)1.34 (1.09–1.64)1.61 (1.29–2.03)1.36 (1.05–1.76)<0.001
  Glucose-lowering medication>0.25
   No use1.001.55 (1.18–2.05)1.46 (1.08–1.96)1.71 (1.24–2.37)1.86 (1.32–2.62)0.001
   Oral hypoglycemic agents1.001.11 (0.85–1.45)1.33 (1.02–1.73)1.44 (1.07–1.93)1.60 (1.18–2.18)<0.001
    Metformin1.001.18 (0.95–1.48)1.36 (1.09–1.70)1.62 (1.28–2.05)1.64 (1.29–2.10)<0.001
    Sulfonylureas1.000.98 (0.77–1.24)1.13 (0.90–1.43)1.37 (1.07–1.75)1.35 (1.04–1.76)<0.001
    Other oral agents1.001.18 (0.78–1.78)1.41 (0.94–2.09)1.56 (1.03–2.35)1.79 (1.18–2.71)<0.001
   Insulin1.001.18 (0.95–1.46)1.32 (1.06–1.64)1.64 (1.31–2.05)1.63 (1.29–2.07)<0.001
 Women
  Age groups (years)>0.25
   <501.001.11 (0.87–1.40)1.16 (0.92–1.45)1.21 (0.97–1.52)1.14 (0.92–1.42)0.18
   50–591.001.01 (0.82–1.24)0.93 (0.76–1.14)1.11 (0.90–1.36)1.15 (0.94–1.40)0.030
   ≥601.000.87 (0.71–1.07)0.84 (0.69–1.03)1.04 (0.84–1.29)1.01 (0.81–1.27)0.42
  Race>0.25
   African American1.000.94 (0.80–1.10)0.97 (0.83–1.14)1.11 (0.95–1.31)1.15 (0.98–1.36)<0.001
   White1.001.06 (0.89–1.28)1.01 (0.84–1.20)1.19 (1.00–1.43)1.15 (0.96–1.38)0.044
  Smoking status>0.90
   Never1.000.99 (0.83–1.18)1.01 (0.86–1.20)1.15 (0.96–1.36)1.19 (1.01–1.42)<0.001
   Ever or current1.001.14 (0.92–1.41)1.15 (0.93–1.42)1.31 (1.06–1.64)1.20 (0.96–1.49)0.036
  Glucose-lowering medication>0.10
   No use1.001.08 (0.84–1.40)1.06 (0.82–1.37)1.33 (1.02–1.73)1.38 (1.06–1.79)0.002
   Oral hypoglycemic agents1.000.96 (0.77–1.20)0.94 (0.76–1.17)0.94 (0.75–1.18)0.90 (0.72–1.13)0.35
    Metformin1.001.11 (0.91–1.35)1.13 (0.93–1.37)1.21 (0.99–1.47)1.21 (0.99–1.47)0.035
    Sulfonylureas1.000.99 (0.79–1.24)1.01 (0.82–1.25)1.08 (0.87–1.35)1.08 (0.87–1.35)0.17
    Other oral agents1.000.96 (0.71–1.31)0.82 (0.61–1.11)0.88 (0.64–1.20)0.92 (0.68–1.25)0.76
   Insulin1.001.05 (0.85–1.31)1.10 (0.89–1.35)1.26 (1.02–1.56)1.29 (1.05–1.59)<0.001
Last visit
 Men
  Age groups (years)>0.25
   <501.001.03 (0.83–1.28)1.14 (0.92–1.41)1.45 (1.16–1.81)1.50 (1.20–1.87)<0.001
   50–591.001.25 (1.01–1.55)1.37 (1.10–1.69)1.56 (1.24–1.96)1.50 (1.19–1.91)<0.001
   ≥601.001.10 (0.89–1.36)1.13 (0.90–1.41)1.24 (0.95–1.63)1.17 (0.86–1.60)0.09
  Race>0.10
   African American1.001.06 (0.89–1.25)1.15 (0.97–1.36)1.42 (1.17–1.72)1.61 (1.32–1.97)<0.001
   White1.001.26 (1.04–1.51)1.36 (1.13–1.64)1.58 (1.30–1.93)1.53 (1.25–1.87)<0.001
  Smoking status>0.05
   Never1.001.25 (1.02–1.52)1.44 (1.19–1.76)1.66 (1.35–2.05)1.95 (1.58–2.41)<0.001
   Ever or current1.001.15 (0.95–1.38)1.19 (0.98–1.44)1.50 (1.20–1.88)1.25 (0.98–1.59)0.003
  Glucose-lowering medication>0.10
   No use1.001.54 (1.19–2.00)1.41 (1.06–1.86)1.69 (1.25–2.30)1.65 (1.18–2.32)0.004
   Oral hypoglycemic agents1.001.06 (0.83–1.36)1.32 (1.03–1.69)1.42 (1.08–1.88)1.61 (1.21–2.14)<0.001
    Metformin1.000.99 (0.82–1.21)1.23 (1.01–1.49)1.40 (1.13–1.73)1.48 (1.19–1.83)<0.001
    Sulfonylureas1.000.97 (0.78–1.21)1.19 (0.96–1.47)1.40 (1.11–1.78)1.34 (1.06–1.71)<0.001
    Other oral agents1.000.97 (0.66–1.41)1.26 (0.88–1.81)1.38 (0.94–2.02)1.46 (1.00–2.14)<0.001
   Insulin1.001.04 (0.85–1.26)1.22 (1.00–1.48)1.38 (1.12–1.70)1.47 (1.19–1.82)<0.001
 Women
  Age groups (years)>0.25
   <501.000.93 (0.75–1.14)0.97 (0.79–1.19)1.04 (0.85–1.28)0.96 (0.79–1.16)0.75
   50–591.000.86 (0.72–1.04)0.86 (0.72–1.03)0.99 (0.83–1.20)1.05 (0.87–1.25)0.055
   ≥601.000.87 (0.72–1.05)0.80 (0.66–0.97)0.99 (0.81–1.22)1.02 (0.82–1.27)0.66
  Race>0.25
   African American1.000.83 (0.72–0.97)0.88 (0.76–1.02)1.02 (0.88–1.19)1.04 (0.90–1.21)0.001
   White1.000.97 (0.82–1.15)0.93 (0.79–1.09)1.08 (0.91–1.28)1.06 (0.90–1.25)0.14
  Smoking status>0.90
   Never1.000.88 (0.75–1.03)0.92 (0.79–1.07)1.05 (0.90–1.23)1.07 (0.92–1.25)0.005
   Ever or current1.001.03 (0.84–1.26)1.06 (0.87–1.29)1.18 (0.96–1.45)1.08 (0.88–1.33)0.26
  Glucose-lowering medication0.262
   No use1.000.93 (0.73–1.19)1.15 (0.91–1.45)1.13 (0.88–1.45)1.23 (0.96–1.58)0.016
   Oral hypoglycemic agents1.000.94 (0.77–1.14)0.87 (0.71–1.06)0.95 (0.77–1.17)0.85 (0.69–1.05)0.23
    Metformin1.001.02 (0.86–1.22)0.97 (0.82–1.16)1.14 (0.96–1.36)1.08 (0.91–1.29)0.11
    Sulfonylureas1.000.91 (0.74–1.11)0.88 (0.72–1.07)1.05 (0.86–1.28)0.97 (0.79–1.18)0.39
    Other oral agents1.000.83 (0.63–1.08)0.74 (0.57–0.96)0.81 (0.62–1.06)0.80 (0.62–1.04)0.40
   Insulin1.000.85 (0.70–1.03)0.88 (0.73–1.05)1.07 (0.89–1.30)1.03 (0.86–1.24)0.013
  • aAdjusted for age, race, types of insurance, income, and smoking, other than the variable for stratification.