Table 3

BMI and mortality risk in participants with diabetes: sensitivity analysis

No. participantsNo. eventsEvent rateModel 1Model 2Model 3
Diabetes from self-report, medications, and HbA1c ≥6.5%
 Overweight40811540.71.001.001.00
 Obese2476337.60.94 (0.69–1.28)1.23 (0.90–1.69)0.95 (0.64–1.42)
 Normal weight2638445.61.12 (0.85–1.48)1.8 (0.82–1.44)1.49 (1.06–2.09)
 Normal weight + thigh muscle1.21 (0.86–1.71)
 Normal weight + gait speed1.39 (0.98–1.96)
 BMI per SD increment63718846.80.95 (0.83–1.09)1.09 (0.94–1.27)0.98 (0.71–1.36)
Excluding participants who died within first 2 years
 Overweight2787037.81.001.001.00
 Obese1085236.21.04 (0.91–1.18)1.29 (0.89–1.88)0.99 (0.62–1.59)
 Normal weight1083550.51.35 (1.21–1.50)1.38 (0.91–2.08)1.63 (1.02–2.62)
 Normal weight + thigh muscle1.33 (0.81–2.17)
 Normal weight + gait speed1.39 (0.85–2.27)
Excluding participants reporting current or former smoking
 Overweight1093245.11.001.001.00
 Obese851933.90.75 (0.43–1.32)1.08 (0.60–1.95)0.73 (0.36–1.51)
 Normal541751.01.15 (0.64–2.07)1.28 (0.70–2.33)1.83 (0.90–3.70)
  • Data are HR (95% CI) unless otherwise indicated. Events per 1,000 person-years. Model 1 unadjusted. Model 2 adjusted for age, sex, education, and duration of diabetes. Model 3 adjusted for model 2 covariates plus midlife BMI, waist circumference, total cholesterol, HDL cholesterol, systolic blood pressure, smoking status, hypertension, statin use, diabetes medication type, microalbuminuria, and CRP.