Table 1—

Definitions for hypertension and hypercholesterolemia during the 10-year follow-up period in the EDC

Exams 1–4 (1986–1993)Exams 5 and 6 (1994–1998)
Hypertension
    Case definition>140/90 mmHg or treatment with antihypertensive medication*130/85 mmHg or treatment with antihypertensive medication*
    Goal for treatment<140/90 mmHg<130/85 mmHg
Hypercholesterolemia
    Case definitionAbove LDL cholesterol goal or treatment with anihyperlipidemic medication
    Goal for treatment
•LDL cholesterol <160 mg/dl if less than two risk factors•<160 mg/dl if less than two risk factors§
•Initiate medication therapy if >190 mg/dl•Initiate medication therapy if >190 mg/dl
oror
•LDL cholesterol <130 mg/dl if CAD or two or more risk factors‡•<130 mg if two or more risk factors
•Initiate medication therapy if >160 mg/dl•Initiate medication therapy if >160 mg/dl
or
•<100 mg /dl if CAD
•Initiate medication therapy if >130 mg/dl
  • *

    * Antihypertensive medications include ACE inhibitors, β-blockers, calcium channel blockers, diuretics, and other antihypertensives. Subjects also had to indicate that the reason for taking the medication was hypertension. If the reason was not hypertension, subjects were not considered to be taking an antihypertensive medication. If no reason was listed, the presumption was antihypertensive use.

  • Lipid-lowering medications include HMG-COA reductase inhibitors, fish oil (more than six capsules per day), bile acid resins, probucol, and niacin ≥750 mg/day.

  • Male sex, smoker, hypertension, family history of premature coronary heart disease, HDL cholesterol <35 mg/dl, diabetes, cerebrovascular or peripheral vascular disease, and BMI >45 kg/m2.

  • §

    § Male age >45 years, female age >55 or postmenopausal without hormone replacement therapy, family history of premature coronary heart disease, smoker, hypertension, HDL cholesterol <35 mg/dl, and diabetes.