Table 3—

Oral symptomatic therapy of painful neuropathy

Drug classDrugDaily dose (mg)NNTNNHSide effects
TricyclicsAmitriptyline25–1502.4 (2.0–3.0)2.7 (2.1–3.9)++++
Imipramine25–1502.4 (2.0–3.0)2.7 (2.1–3.9)++++
SSRIsParoxetine40NDND+++
Citalopram40NDND+++
AnticonvulsantsGabapentin900–1,8003.7 (2.4–8.3)2.7 (2.2–3.4)++
Pregabalin150–6003.3 (2.3–5.9)3.7++
Carbamazepine200–4003.3 (2.0–9.4)1.9 (1.4–2.8)+++
TopiramateUp to 4003.0 (2.3–4.5)9.0++
OpioidsTramadol50–4003.4 (2.3–6.4)7.8+++
Oxycodone CR10–60NDND++++
  • Data are median (range) unless otherwise indicated. See refs. 2, 19, and 20. ND, not determined; NNH, number needed to treat to harm one patient; NNT, number needed to treat to achieve pain relief in one patient; SSRI, selective serotonin reuptake inhibitor.