Table 2—

Mean pharmacokinetic summary measures after inhalation of 6 mg INH or subcutaneous injection of 18 U RHI on two different study days in 17 healthy volunteers (baseline values subtracted)

Serum insulin measures	INH	RHI	Ratio/difference*	90% CI*	P values†
Maximal serum insulin concentration (C_max) (μU/ml)‡	66.9	61.0	110% (INH/RHI)	86–139	NS
Time to maximal concentration (t_max) (min)*	55	148	−93 (INH−RHI)	−132 to −54	< 0.001
AUC-Insulin_0–60 (μU · ml^–1 · min⁻¹)‡	2,740	1,650	166% (INH/RHI)	120–229	< 0.05
AUC-Insulin_0–180 (μU · ml^–1 · min^–1)‡	8,390	7,560	111% (INH/RHI)	90–137	NS
AUC-Insulin_0–600 (μU · ml^–1 · min^–1)‡	14,000	17,700	79% (INH/RHI)	67–92	< 0.05

*
↵* Arithmetic mean;
†
↵† one-sided for t_max and AUC-Insulin_0–60, two-sided for all other measures;
‡
↵‡ geometric mean.