Table 2—

Metabolic parameters in ESRD type 1 diabetic kidney transplant patients with or without a functioning islet transplant

Kidney-islet group
Kidney-only group
BaselineYear 3BaselineYear 3
Creatinine (mg/dl)1.4 ± 0.11.6 ± 0.21.6 ± 0.31.7 ± 0.3
GHb (%)7.7 ± 0.37.7 ± 0.28.6 ± 0.68.1 ± 0.5
Exogenous insulin requirement (U/day)25.2 ± 4.3*17.3 ± 3.4*32.1 ± 7.0*35.1 ± 4.4*
Fasting glucose (mg/dl)216.5 ± 28.8192.8 ± 24.4195.1 ± 29.3231.1 ± 41.4
Systolic blood pressure (mmHg)139.6 ± 4.0143.0 ± 5.2146.0 ± 4.9150.1 ± 4.6
Diastolic blood pressure (mmHg)81.8 ± 2.685.3 ± 1.886.1 ± 2.888.5 ± 1.4
Cholesterol (mg/dl)214.6 ± 11.1202.3 ± 12.8196.8 ± 20.02199.8 ± 11.5
Triglycerides (mg/dl)121.4 ± 14.2130.8 ± 15.9110.0 ± 18.5112.5 ± 16.0
Cyclosporin (ng/ml)174.5 ± 16.5155.9 ± 9.6150.6 ± 8.7163.8 ± 26.0
HDL (mg/ml)65.7 ± 6.865.4 ± 3.957.1 ± 6.155.8 ± 5.0
LDL (mg/ml)114.8 ± 12.7117.0 ± 8.4125.3 ± 15.1112.0 ± 8.6
Prednisone (mg/day)7.3 ± 1.23.5 ± 0.87.5 ± 0.94.6 ± 0.8
Verapamil6183
β-Blockers4141
Digoxin-amiodarone1133
ACE75108
Statin1212
  • Data are means ± SE or n. Exogenous insulin requirement is lower in the kidney islet group.

  • *

    * Kidney-islet versus kidney-only both at baseline and year 3, P < 0.05.

  • Kidney-islet showed a statistical reduction of insulin requirements, P < 0.05.