Table 1—

Baseline characteristics across quartiles of sTNF-RII among 929 women with type 2 diabetes: the NHS

Quartiles of sTNF-RII
1234
Median sTNF-RII (pg/ml)1768.62205.12616.73322.7
Range sTNF-RII (pg/ml)1,005.1–2,006.82,010.8–2,370.62,373.2–2,888.12,891.6–9,355.3
Age (years)56.657.759.060.0
BMI (kg/m2)27.329.230.932.4
Current smokers32 (14)25 (11)39 (17)35 (14)
Physical activity (h/week)3.02.82.82.3
Alcohol consumption (g/day)4.52.72.21.9
Duration of type 2 diabetes (years)7.47.97.19.1
Daily aspirin use74 (33)72 (32)81 (35)87 (35)
Postmenopausal hormone use68 (30)66 (29)62 (27)57 (23)
Insulin use32 (14)36 (16)39 (17)72 (29)
Oral diabetic medication use38 (17)52 (23)42 (18)54 (22)
Multivitamin supplement use95 (42)86 (38)79 (34)94 (38)
History of hypertension115 (51)120 (53)143 (62)170 (69)
History of hypercholesterolemia126 (56)118 (52)120 (52)131 (53)
History of angina pectoris27 (12)18 (8)28 (12)27 (11)
Parental history of MI43 (19)56 (25)55 (24)59 (24)
Biomarkers
HbA1c (%)6.456.876.807.29
CRP (mg/l)*4.77.28.811.7
sICAM-1 (ng/ml)271.1290.6325.5374.6
sE-selectin (ng/ml)55.760.068.579.5
Fibrinogen (mg/dl)349.4367.5386.2397.4
Triglycerides (mg/dl) 187.2203.0200.3217.7
HDL cholesterol (mg/dl)56.052.649.548.6
LDL cholesterol (mg/dl)145.5137.7138.7135.2
Apolipoprotein B100 (mg/dl)103.4101.9101.7102.1
Total cholesterol–to–HDL cholesterol ratio4.64.74.74.9
  • Data are n (%) unless otherwise indicated. Means and percentages (except for age) are age adjusted for the age-groups: <49, 50–54, 55–59, 60–64, and ≥65 years.

  • *

    * According to a regression between two CRP assays among subgroup of 204 diabetic women (r = 0.97 corrected CRP = 0.4 + 0.67x).

  • Similar levels among 622 women who reported fasting >8 h before blood was drawn.