Table 2—

Relative risks of MI, CABG/PTCA, and total CHD events across quartiles of sTNF-RII among 929 women with type 2 diabetes: the NHS

Quartiles of sTNF-RII
1234P value
Median (pg/ml)1,768.62,205.12,616.73,322.7
MI (fatal + nonfatal)
    n8161628
    Age adjusted1.001.89 (0.81–4.41)1.80 (0.77–4.22)3.01 (1.37–6.64)0.005
    MV*1.001.86 (0.78–4.41)1.62 (0.67–3.88)2.48 (1.08–5.69)0.034
CABG/PTCA
    n1361423
    Age adjusted1.000.46 (0.18–1.22)1.04 (0.48–2.22)1.64 (0.82–3.27)0.031
    MV*1.000.53 (0.20–1.41)1.07 (0.49–2.37)1.77 (0.84–3.70)0.041
CHD (MI + CABG/PTCA)
    n21223051
    Age adjusted1.001.02 (0.56–1.85)1.33 (0.76–2.33)2.16 (1.29–3.62)<0.001
    MV*1.001.09 (0.60–2.01)1.28 (0.72–2.29)2.02 (1.17–3.48)0.003
    MV + duration of type 2 diabetes1.02 (0.55–1.87)1.25 (0.67–2.22)1.87 (1.08–3.23)0.007
    MV + TGs1.001.11 (0.61–2.04)1.26 (0.70–2.24)1.99 (1.16–3.45)0.005
    MV + HbA1c1.001.03 (0.56–1.89)1.19 (0.67–2.13)1.79 (1.04–3.10)0.014
    MV + CRP1.001.08 (0.59–1.99)1.27 (0.71–2.28)2.04 (1.17–3.56)0.004
    MV + HbA1c + CRP1.001.03 (0.56–1.90)1.21 (0.68–2.16)1.86 (1.06–3.25)0.011
  • Data are RR (95% CI) unless noted.

  • *

    * Multivariate model (MV), Cox regression, adjusted for age (<49, 50–54, 55–59, 60–64, ≥65 years), smoking (current, past, never), BMI (<23, 23–25, 25–28, 28–30, 30–34, ≥35 kg/m2), alcohol intake (0, 0.1–4.9, ≥5 g/day), physical activity (0–1, 1–2, 2–4, ≥4 h/week), postmenopausal hormone use (premenopausal, current, past, never, missing), aspirin use (nondaily, daily), parental history of MI, history of hypertension, history of reported angina pectoris, and ratio of total cholesterol to HDL (quartiles).