Table 2—

Results of the methodological quality assessment by use of the internal validity criteria of the Maastricht-Amsterdam list (23)

CriteriaFontbonne (14)Allen (30)Muchmore (29)Schwedes (31)Guerci (32)Davidson (33)
Was the method of randomization adequate?++++++
Was the treatment allocation concealed??????
Were the groups similar at baseline regarding the most important prognostic indicators?++++++
Was the patient blinded to the intervention?NANANANANANA
Was the care provider blinded to the intervention?NANANANANANA
Was the outcome assessor blinded to the intervention??????+
Were cointerventions avoided or comparable??+?++
Was the compliance acceptable in both groups?++++?
Was the withdrawal/drop-out rate described and acceptable?+++++
Was the timing of the outcome assessment in all groups similar?++++++
Did the analysis include an intention-to-treat analysis???++
Total quality score565557
  • NA, not applicable for this type of intervention; +, criteria answered with “yes”; −, criteria answered with “no”; ?, criteria answered with “don’t know”.