Table 3—

Influence of diabetes onset age-group on subjectively rated macroscopic MRI scan appearances and brain volumes

Early-onset groupLater-onset groupEffect of diabetes onset age-group
Ventricular atrophy (% of scans)
    Total6120OR = 4.6, P = 0.01*
    Mild5013
    Moderate117
Gyral atrophy (% of scans)97NS*
High-intensity WMLs (% of scans)
    Wahlund5924OR = 4.5, P = 0.007*
    Longstreth5553NS*
    Van Swieten (superficial/deep WMLs)0/02/2NS/NS*
    Breteler1827NS*
    Fazekas (superficial/deep WMLs)55/060/18NS/NS*
    Shimada011NS*
    Mirsen (superficial/deep WMLs)1/042/9NS/NS*
Small punctate WMLs (% of scans)
    Hippocampal1420.03*
    Basal ganglia5200.38*
    Centrum semiovale9220.08*
    % with punctate WMLs18400.17*
Brain volume (cm3)
    Whole brain1,270 (1,244–1,296)1,258 (1,240–1,275)F = 0.58, P = 0.45, Eta2 = 0.01
    Lateral ventricle24.5 (21.4–27.6)17.9 (15.8–20.0)F = 11.1, P = 0.002, Eta2 = 0.16
    Right temporal lobe76 (74–79)76 (75–78)F = 0.01, P = 0.92, Eta2 < 0.01
    Left temporal lobe72 (69–74)73 (71–75)F = 0.48, P = 0.49, Eta2 = 0.01
    Right amygdalohippocampal complex4.3 (4.0–4.5)4.4 (4.2–4.6)F = 0.87, P = 0.35, Eta2 = 0.02
    Left amygdalohippocampal complex4.2 (4.0–4.5)4.3 (4.2–4.5)F = 0.41, P = 0.53, Eta2 = 0.01
  • Data are n (range).

  • *

    * Determined by binary logistic regression;

  • determined by multiple ANCOVA. NS, nonsignificant onset age-group effect in the final logistic regression model. OR, odds ratio.