Table 1—

Baseline characteristics of 592 type 1 diabetic patients, subdivided according to BMI

Normal-weight men (group 1)Normal-weight women (group 2)Overweight men (group 3)Overweight women (group 4)ANOVA (P)Post hoc
Group 1 vs. 3Group 2 vs. 4
n168146156122
Age (years)40 ± 1239 ± 1144 ± 1242 ± 12<0.00010.003NS
Duration (years)17 ± 1017 ± 1021 ± 1221 ± 100.0010.0190.014
BMI (kg/m2)22.5 ± 1.822.3 ± 1.628.0 ± 3.529.1 ± 4.1<0.0001<0.0001<0.0001
Insulin dose (units/kg)0.73 ± 0.240.69 ± 0.240.71 ± 0.250.72 ± 0.26NS
A1C (%)7.8 ± 1.27.8 ± 1.27.9 ± 1.17.9 ± 1.1NS
Total cholesterol (mg/dl)181 ± 33199 ± 35198 ± 38199 ± 37<0.0001<0.0001NS
Non-HDL cholesterol (mg/dl)119 ± 32113 ± 38142 ± 36110 ± 33<0.0001<0.0001NS
LDL cholesterol (mg/dl)101 ± 29122 ± 40119 ± 33126 ± 39<0.0001<0.0001NS
HDL cholesterol (mg/dl)62 ± 1775 ± 1856 ± 1873 ± 17<0.00010.011NS
Triglycerides (mg/dl)91 ± 4987 ± 61118 ± 8781 ± 330.0010.002NS
Leptin (ng/ml) (tested: 130)4.8 ± 2.710.5 ± 4.88.6 ± 5.925.9 ± 11.3<0.00010.087<0.0001
Adiponectin (μg/ml) (n = 130)15.3 ± 5.520.1 ± 7.312.9 ± 5.915.7 ± 5.4<0.0001NS0.028
χ2
Hypertension50 (30)55 (38)84 (54)47 (39)<0.00011 + 2 vs. 3 + 4: P = 0.001
Retinopathy81 (48)60 (41)98 (63)76 (62)<0.00011 + 2 vs. 3 + 4: P < 0.0001
Neuropathy73 (43)46 (31)90 (58)46 (38)<0.00011 + 2 vs. 3 + 4: P = 0.008
  • Data are means ± SD or n (%), unless otherwise indicated. Overweight is defined as a BMI ≥25 kg/m2 and hypertension as blood pressure >130/85 mmHg. Leptin and adiponectin were tested in a subgroup of 130 patients.