Table 3—

Adjusted effect of insulin treatment on change in weight (kg) and change in BMI (kg/m2) from 0 to 2 years

ModelCovariatesWeight models
BMI models
nΔWt ± SE due to insulin treatmentP*nΔBMI ± SE due to insulin treatmentP
1Unadjusted1000.38 ± 0.860.66970.04 ± 0.250.89
2Model 1 + sex, baseline age, and baseline Tanner stage940.79 ± 0.900.38910.01 ± 0.260.96
3Model 2 + baseline BMI910.71 ± 0.930.44910.01 ± 0.260.98
4Model 3 + baseline glucose tolerance910.85 ± 0.920.36910.07 ± 0.250.79
5Model 4 + Δ Tanner stage from 0 to 2 years880.40 ± 0.800.61880.002 ± 0.250.99
6Model 5 + average rate of hypoglycemic events from 0 to 2 years880.51 ± 0.810.53880.02 ± 0.250.95
  • *

    * P value for effect of insulin treatment on change in weight from multiple regression.

  • P value for effect of insulin treatment on change in BMI from multiple regression.

  • Eight subjects had Tanner stage that dropped by 1 from baseline to 2 years (seven of these were from Tanner stage 5 to Tanner stage 4). These eight measurements of −1 were reassigned to 0.