Table 1—

Baseline demographic and risk factor rates by fundus severity score categories

RetinopathyNoneFundus severity score
Below medianAbove medianP value*
Minimal NPDRModerate to severe NPDRPDR
Score10–1415–3940–5960+10–3940+
Patients (n)48551120879996287NS
Hispanic (%)171725351728<0.05
Non-Hispanic white (%)676250476449<0.01
African American (%)161924201723<0.05
Age (years)606160616060NS
Duration of diabetes (years)71214171015<0.05
Smoking (years)262623242623<0.05
A1C (%)9.39.49.79.49.39.6<0.05
Fasting glucose (mg/dl)189191196193190195NS
UACR (mg/g)4812319815987187<0.01
Hypertension (%)727174807276NS
Systolic blood pressure (mmHg)129133136136131136<0.05
Diastolic blood pressure (mmHg)767678767677NS
Amputation (%)0.82.53.83.81.73.8<0.05
Stroke (%)5.26.15.83.85.65.2NS
Cardiac revascularization %162520222120NS
Triglycerides (mg/dl)242205196176223190<0.05
Total cholesterol (mg/dl)188188185182188184NS
LDL cholesterol (mg/dl)108112111108110110NS
HDL cholesterol (mg/dl)393940393939NS
Fibrinogen (mg/dl)421383384384402384NS
PAI-1484343354541<0.05
  • *

    * All comparisons are between combined fundus severity scores above the median compared to those below the median. UACR, urine albumin-to-creatinine ratio.