Clinical and biochemical characteristics according to the C-174G polymorphism of the IL-6 gene in 275 nondiabetic individuals
| IL-6 promoter genotypes | *P | †P (G/G vs. C/G + C/C) | |||||
|---|---|---|---|---|---|---|---|
| G/G | G/C | C/C | |||||
| Male/female (n) | 42/100 | 36/76 | 7/14 | 0.88 | 0.62 | ||
| Age (years) | 39 ± 12 (37) | 37 ± 11 (37) | 39 ± 10 (41) | 0.48 | 0.43 | ||
| BMI (kg/m2) | 31.2 ± 8.9 (28) | 29.4 ± 8.8 (27) | 28.5 ± 4.5 (28) | 0.17 | 0.13 | ||
| Waist-to-hip ratio | 0.87 ± 0.10 (0.87) | 0.86 ± 0.09 (0.86) | 0.85 ± 0.09 (0.85) | 0.80 | 0.80 | ||
| Total fat mass (%) | 37 ± 15 (36) | 36 ± 14 (35) | 32 ± 8 (31) | 0.31 | 0.23 | ||
| Fasting glucose (mg/dl) | 95 ± 23 (92) | 91 ± 12 (91) | 91 ± 10 (92) | 0.33 | 0.29 | ||
| 2-h glucose (mg/dl) | 120 ± 42 (110) | 110 ± 31 (107) | 104 ± 26 (105) | 0.08 | 0.09 | ||
| Fasting insulin (μU/ml) | 12 ± 8 (10) | 11 ± 9 (10) | 11 ± 7 (10) | 0.34 | 0.09 | ||
| 2-h insulin (μU/ml) | 66 ± 55 (47) | 62 ± 75 (47) | 64 ± 85 (43) | 0.27 | 0.19 | ||
| Total cholesterol (mg/dl) | 199 ± 42 (197) | 195 ± 36 (192) | 196 ± 36 (203) | 0.73 | 0.43 | ||
| HDL cholesterol (mg/dl) | 53 ± 13 (52) | 53 ± 14 (52) | 50 ± 13 (49) | 0.50 | 0.57 | ||
| Triglycerides (mg/dl) | 122 ± 83 (94) | 123 ± 71 (107) | 116 ± 47 (105) | 0.84 | 0.32 | ||
| Fibrinogen (mg/dl) | 303 ± 83 (294) | 282 ± 63 (275)‡ | 289 ± 56 (270) | 0.08 | 0.02 | ||
| White blood cell count (× 109/ml ) | 7,444 ± 1,998 (7,100) | 6,872 ± 1,468 (7,020)§ | 6,171 ± 1,457 (6,140)‖ | 0.04 | 0.03 | ||
| Family history of T2DM (n yes/no) | 102/39 | 88/24 | 19/2 | 0.14 | 0.11 | ||
| NGT/IGT (n) | 114/28 | 94/18 | 19/2 | 0.22 | 0.30 | ||
| Glucose disposal (mg · kg–1 · min–1) | 6.8 ± 2.9 (7.0) | 7.8 ± 3.3 (7.7)¶ | 8.2 ± 3.3 (7.8)# | 0.01 | 0.004 | ||
| Fasting IL-6 (pg/ml) | 2.5 ± 3.2 (1.7) | 1.6 ± 1.4 (1.1)** | 1.5 ± 0.8 (1.4) | 0.07 | 0.02 | ||
Data are means ± SD (median) unless otherwise indicated.
↵* P values for comparisons of differences of continuous variables between the three genotypes using ANOVA.
↵† P values for comparisons of differences of continuous variables between two genotypes using unpaired Student’s t or Mann-Whitney U test. Categorical variables were compared by χ2 test.
↵‡ P = 0.03 vs. G/G,
↵§ P = 0.05 vs. G/G,
↵‖ P = 0.03 vs. G/G,
↵¶ P= 0.01 vs. G/G,
↵# P = 0.05 vs. G/G,
↵** P = 0.03 vs. G/G genotype after least significant difference correction for multiple comparisons. IGT, impaired glucose tolerance; NGT, normal glucose tolerance; T2DM, type 2 diabetes.