Table 1—

Clinical and biochemical characteristics according to the C-174G polymorphism of the IL-6 gene in 275 nondiabetic individuals

IL-6 promoter genotypes
*PP (G/G vs. C/G + C/C)
G/GG/CC/C
Male/female (n)42/10036/767/140.880.62
Age (years)39 ± 12 (37)37 ± 11 (37)39 ± 10 (41)0.480.43
BMI (kg/m2)31.2 ± 8.9 (28)29.4 ± 8.8 (27)28.5 ± 4.5 (28)0.170.13
Waist-to-hip ratio0.87 ± 0.10 (0.87)0.86 ± 0.09 (0.86)0.85 ± 0.09 (0.85)0.800.80
Total fat mass (%)37 ± 15 (36)36 ± 14 (35)32 ± 8 (31)0.310.23
Fasting glucose (mg/dl)95 ± 23 (92)91 ± 12 (91)91 ± 10 (92)0.330.29
2-h glucose (mg/dl)120 ± 42 (110)110 ± 31 (107)104 ± 26 (105)0.080.09
Fasting insulin (μU/ml)12 ± 8 (10)11 ± 9 (10)11 ± 7 (10)0.340.09
2-h insulin (μU/ml)66 ± 55 (47)62 ± 75 (47)64 ± 85 (43)0.270.19
Total cholesterol (mg/dl)199 ± 42 (197)195 ± 36 (192)196 ± 36 (203)0.730.43
HDL cholesterol (mg/dl)53 ± 13 (52)53 ± 14 (52)50 ± 13 (49)0.500.57
Triglycerides (mg/dl)122 ± 83 (94)123 ± 71 (107)116 ± 47 (105)0.840.32
Fibrinogen (mg/dl)303 ± 83 (294)282 ± 63 (275)289 ± 56 (270)0.080.02
White blood cell count (× 109/ml )7,444 ± 1,998 (7,100)6,872 ± 1,468 (7,020)§6,171 ± 1,457 (6,140)0.040.03
Family history of T2DM (n yes/no)102/3988/2419/20.140.11
NGT/IGT (n)114/2894/1819/20.220.30
Glucose disposal (mg · kg–1 · min–1)6.8 ± 2.9 (7.0)7.8 ± 3.3 (7.7)8.2 ± 3.3 (7.8)#0.010.004
Fasting IL-6 (pg/ml)2.5 ± 3.2 (1.7)1.6 ± 1.4 (1.1)**1.5 ± 0.8 (1.4)0.070.02
  • Data are means ± SD (median) unless otherwise indicated.

  • *

    * P values for comparisons of differences of continuous variables between the three genotypes using ANOVA.

  • P values for comparisons of differences of continuous variables between two genotypes using unpaired Student’s t or Mann-Whitney U test. Categorical variables were compared by χ2 test.

  • P = 0.03 vs. G/G,

  • §

    § P = 0.05 vs. G/G,

  • P = 0.03 vs. G/G,

  • P= 0.01 vs. G/G,

  • #

    # P = 0.05 vs. G/G,

  • **

    ** P = 0.03 vs. G/G genotype after least significant difference correction for multiple comparisons. IGT, impaired glucose tolerance; NGT, normal glucose tolerance; T2DM, type 2 diabetes.