Table 2—

Clinical and biochemical characteristics according to the C-174G polymorphism of the IL-6 gene in 77 obese subjects who underwent LAGB

IL-6 promoter genotypes
*PP (G/G vs. G/C + C/C)
G/GG/CC/C
Male/female (n)4/334/302/40.300.58
Age (years)39 ± 9 (39)39 ± 10 (38)44 ± 10 (41)0.560.60
Weight (kg)116 ± 17 (113)127 ± 24 (124)119 ± 10 (122)0.080.04
BMI (kg/m2)43.6 ± 5.3 (44.0)47.5 ± 8.1 (45.6)42.8 ± 4.0 (43.1)0.040.09
Waist-to-hip ratio0.86 ± 0.07 (0.85)0.87 ± 0.07 (0.86)0.89 ± 0.1 (0.87)0.680.26
Ultrasound thickness of VAT (mm)84.3 ± 23.3 (79)89.3 ± 26.9 (88)95.3 ± 30.1 (108)0.710.46
Ultrasound thickness of SAT (mm)46.0 ± 8.7 (46)48.9 ± 8.7 (51)44.3 ± 15.5 (38)0.560.50
CT scan area of VAT (mm2)170 ± 26 (126)203 ± 55 (162)215 ± 60 (188)0.660.74
CT scan area of SAT (mm2)493 ± 83 (480)503 ± 80 (452)523 ± 90 (497)0.790.81
VAT-to-SAT ratio0.55 ± 0.45 (0.23)0.44 ± 0.51 (0.32)0.41 ± 0.70 (0.25)0.820.58
Fasting glucose (mg/dl)110 ± 26 (102)113 ± 36 (102)113 ± 36 (105)0.960.82
2-h glucose (mg/dl)143 ± 50 (137)174 ± 90 (155)174 ± 90 (156)0.140.11
Fasting insulin (μU/ml)21 ± 9 (17)17 ± 7 (15)11 ± 3 (10)§0.020.04
2-h insulin (μU/ml)78 ± 50 (75)88 ± 75 (65)81 ± 95 (54)0.850.55
A1C (%)6.0 ± 1.3 (5.7)6.4 ± 1.4 (6.2)5.9 ± 1.4 (5.8)0.450.23
Total cholesterol (mg/dl)189 ± 41 (182)220 ± 39 (210)204 ± 19 (198)0.0060.007
HDL cholesterol (mg/dl)47 ± 12 (46)51 ± 22 (46)37 ± 7 (40)0.250.90
Triglycerides (mg/dl)135 ± 69 (124)179 ± 139 (148)179 ± 139 (123)#0.0060.04
HOMA6.4 ± 5.9 (4.5)4.5 ± 2.1 (4.1)3.0 ± 0.5 (3.1)**0.080.07
NGT/IGT/IFG/T2DM (n)24/7/2/418/8/1/73/2/0/10.990.79
IL-6 mRNA levels (arbitrary units)21 ± 19 (13.3)10 ± 12 (7.0)††13 ± 20 (2.4)0.0590.04
  • Data are means ± SD (median) unless otherwise indicated.

  • *

    * P values for comparisons of differences of continuous variables between the three genotypes using ANOVA.

  • P values for comparisons of differences of continuous variables between two genotypes using unpaired Student’s t or Mann-Whitney U test. Categorical variables were compared by χ2 test.

  • P = 0.05 vs. G/G,

  • §

    § P = 0.05 vs. G/G,

  • P = 0.002 vs. G/G,

  • P = 0.007 vs. G/G,

  • #

    # P = 0.002 vs. G/G,

  • **

    ** P = 0.05 vs. G/G, genotype after least significant difference correction for multiple comparisons,

  • ††

    †† P = 0.02 vs. G/G. IFG, impaired fasting glucose; IGT, impaired glucose tolerance; NGT, normal glucose tolerance; SAT, subcutaneous adipose tissue; T2DM, type 2 diabetes; VAT, visceral adipose tissue.