Summary statistics for longitudinal change of nerve tests in group 2 patients
| Nerve test | RDNS patients (of 90) who at baseline had Σ 5 NC nds <97.5th percentile | Significantly worsened vs. improved over time | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Worse* | Better* | Unchanged* | b̄† | P | r̄2‡ | |||||
| Ulnar CMAP nd | 7 | 9 | 74 | 0.001 | 0.8815 | 0.000 | ||||
| Ulnar MNCV nd | 22 | 0 | 68 | −0.043 | <0.0001 | 0.086 | ||||
| Ulnar MNDL nd | 18 | 2 | 70 | 0.059 | <0.0001 | 0.110 | ||||
| Ulnar F-wave nd | 18 | 4 | 68 | 0.028 | <0.0001 | 0.048 | ||||
| Peroneal CMAP nd | 21 | 1 | 68 | −0.033 | <0.0001 | 0.053 | ||||
| Peroneal MNCV nd | 23 | 6 | 61 | −0.054 | <0.0001 | 0.120 | ||||
| Peroneal MNDL nd | 30 | 1 | 59 | 0.082 | <0.0001 | 0.228 | ||||
| Tibial CMAP nd | 16 | 12 | 62 | −0.004 | 0.6130 | 0.000 | ||||
| Tibial MNCV nd | 12 | 1 | 77 | −0.026 | 0.0003 | 0.042 | ||||
| Tibial MNDL nd | 25 | 1 | 64 | 0.085 | <0.0001 | 0.226 | ||||
| Tibial F-wave nd | 15 | 9 | 66 | 0.017 | 0.0410 | 0.023 | ||||
| Sural SNAP nd | 18 | 5 | 67 | −0.044 | <0.0001 | 0.102 | ||||
| Σ 5 NC nds | 42 | 1 | 47 | 0.296 | <0.0001 | 0.354 | ||||
| Σ Per. Tib. Ul. CMAP nds | 16 | 7 | 67 | 0.035 | 0.0170 | 0.017 | ||||
| Σ Per. Tib. CMAP & Sur. SNAP nds | 28 | 1 | 61 | 0.082 | <0.0001 | 0.082 | ||||
| Σ Per. Tib. Ul. MNCV nds | 25 | 0 | 65 | 0.122 | <0.0001 | 0.145 | ||||
| Σ Per. Tib. MNCV & Sur. SNCV nds | 18 | 1 | 71 | 0.122 | <0.0001 | 0.134 | ||||
| Σ Per. Tib. MNCV, Sur. SNCV & Tib. F-wave nds | 21 | 2 | 67 | 0.143 | <0.0001 | 0.119 | ||||
| Σ Per. Tib. Ul. MNCV & Per. Tib. F-wave nds | 28 | 3 | 59 | 0.173 | <0.0001 | 0.119 | ||||
| Σ Per. Tib. Ul. MNDL nds | 35 | 1 | 54 | 0.223 | <0.0001 | 0.290 | ||||
| NIS (total) | 5 | 3 | 82 | 0.032 | 0.0418 | 0.011 | ||||
| NIS (lower leg) | 5 | 4 | 81 | 0.032 | 0.0383 | 0.010 | ||||
| NSC severity (total) | 3 | 1 | 86 | −0.169 | 0.0523 | 0.042 | ||||
| Left foot VDT step nd | 5 | 11 | 74 | −0.020 | 0.0927 | 0.007 | ||||
| ln(Left foot CDT step) nd | 11 | 2 | 77 | 0.024 | 0.0670 | 0.002 | ||||
| Left foot HP: 5 step nd | 4 | 5 | 81 | −0.005 | 0.8535 | 0.006 | ||||
| Left foot HP: 0.5 step nd | 6 | 3 | 81 | −0.013 | 0.6113 | 0.001 | ||||
| Left foot HP: 5–0.5 step nd | 5 | 6 | 79 | −0.016 | 0.5154 | 0.000 | ||||
Data in bold are P values <0.05.
↵* Statistically significant change (P < 0.05) of the nerve test over time of each patient using regression analysis. The mean ±SD number of neuropathic assessments was 7.8 ± 1.2.
↵† Mean slope (b̄) of regression lines of nerve tests on time.
↵‡ Mean of the correlation of nerve tests on time. CDT, cooling detection threshold; CMAP, compound muscle action potential; HP, heat pain; MNCV, motor nerve conduction velocity; MNDL, motor nerve distal latency; Per., peroneal; SNAP, sensory nerve action potential; Sur. sural; Tib., tibial; Ul., ulnar; VDT, vibratory detection threshold.