Table 2

Effects of history of severe hypoglycemia at baseline on macrovascular events at 4-year follow-up

UnadjustedAge/sex adjustedCV risk factor adjusted*Adjusted
OR
(95% CI)P valueOR
(95% CI)P valueOR
(95% CI)P valueOR
(95% CI)P value
Macrovascular disease events2.43
(1.35, 4.38)0.0032.63
(1.45, 4.78)0.0012.26
(1.17, 4.36)0.0152.11
(1.06, 4.21)0.035
Coronary heart disease event3.20
(1.66, 6.14)<0.0013.27
(1.69, 6.33)<0.0012.59
(1.24, 5.41)0.0112.44
(1.13, 5.26)0.023
Cerebrovascular disease event1.19
(0.42, 3.43)0.7421.39
(0.48, 4.03)0.5501.16
(0.36, 3.78)0.8041.01
(0.29, 3.61)0.983
MI4.76
(2.21, 10.23)<0.0014.98
(2.29, 10.84)<0.0013.67
(1.48, 9.07)0.0054.02
(1.54, 10.48)0.004
Stroke1.17
(0.35, 3.92)0.7991.37
(0.40, 4.64)0.6161.02
(0.27, 3.84)0.9780.86
(0.21, 3.56)0.836
  • Sample size: unadjusted n = 1,066; adjusted n = 978. CV, cardiovascular.

  • *Logistic regression adjusted for baseline age, sex, smoking, blood pressure, HbA1c level, cholesterol level, HDL level, BMI, eGFR, microalbuminuria, use of lipid-lowering and blood pressure–lowering medications; and prevalent (baseline) composite macrovascular events, cardiovascular disease events, cerebrovascular disease events, MI, and stroke.

  • †Logistic regression model adjusted for same variables as cardiovascular risk factor–adjusted model, with the addition of baseline diabetes treatment and duration.