Inflammation marker | Unadjusted | Adjusted^{*} | ||
---|---|---|---|---|

Severe hypoglycemia | P value | Severe hypoglycemia | P value | |

CRP (mg/L) | 1.35 (1.04, 1.76) | 0.024 | 1.17 (0.90, 1.53) | 0.236 |

Fibrinogen (g/L) | 0.31 (0.15, 0.48) | <0.001 | 0.12 (−0.05, 0.29) | 0.156 |

IL-6 (pg/mL) | 1.24 (1.07, 1.44) | 0.005 | 1.10 (0.94, 1.28) | 0.242 |

TNF-α (pg/mL) | 1.47 (1.24, 1.74) | <0.001 | 1.27 (1.07, 1.52) | 0.007 |

Inflammation factor^{†} | 0.50 (0.28, 0.72) | <0.001 | 0.24 (0.02, 0.46) | 0.030 |

Values are β (95% CI), unless otherwise indicated. Sample size:

*n*= 953.↵*Multivariate linear model adjusted for age, sex, smoking, blood pressure, HbA

_{1c}level, cholesterol level, HDL level, BMI, eGFR, microalbuminuria, use of lipid-lowering and blood pressure–lowering medications, and baseline diabetes treatment and duration.↵†The general inflammation factor has a mean of 0 and an SD of 1.