Table 3

Association between severe hypoglycemia and inflammation mediators

Inflammation markerUnadjustedAdjusted*
Severe hypoglycemiaP valueSevere hypoglycemiaP value
CRP (mg/L)1.35 (1.04, 1.76)0.0241.17 (0.90, 1.53)0.236
Fibrinogen (g/L)0.31 (0.15, 0.48)<0.0010.12 (−0.05, 0.29)0.156
IL-6 (pg/mL)1.24 (1.07, 1.44)0.0051.10 (0.94, 1.28)0.242
TNF-α (pg/mL)1.47 (1.24, 1.74)<0.0011.27 (1.07, 1.52)0.007
Inflammation factor0.50 (0.28, 0.72)<0.0010.24 (0.02, 0.46)0.030
  • Values are β (95% CI), unless otherwise indicated. Sample size: n = 953.

  • *Multivariate linear model adjusted for age, sex, smoking, blood pressure, HbA1c level, cholesterol level, HDL level, BMI, eGFR, microalbuminuria, use of lipid-lowering and blood pressure–lowering medications, and baseline diabetes treatment and duration.

  • †The general inflammation factor has a mean of 0 and an SD of 1.