Table 1—

Clinical characteristics at baseline and 1 year of weight loss intervention

Orlistat + intervention
Placebo + intervention
BaselineYear 1BaselineYear 1
n1721
Weight (kg)97.0 ± 15.186.9 ± 13*101.8 ± 19.392.4 ± 16.4*
BMI (kg/m2)34.0 ± 5.230.4 ± 4.1*37.0 ± 8.133.6 ± 7.2*
Fasting plasma glucose (mg/dl)182 ± 52138 ± 46154 ± 43119 ± 20
A1C (%)8.1 ± 1.26.7 ± 1.0*7.8 ± 1.56.6 ± 1.1
Fasting plasma insulin (μU/ml)20.7 ± 2.920.2 ± 3.826.6 ± 4.025.8 ± 3.8
Systolic blood pressure (mmHg)127 ± 15131 ± 17131 ± 15128 ± 19
Diastolic blood pressure (mmHg)80 ± 878 ± 681 ± 1281 ± 8
LDL cholesterol (mg/dl)130 ± 35114 ± 37129 ± 27120 ± 27
HDL cholesterol (mg/dl)44 ± 1049 ± 1347 ± 1156 ± 14*
  • Data are means ± SD.

  • * P < 0.01,

  • P < 0.05 year 1 vs. baseline.