Table 2—

Inflammatory markers

Orlistat + intervention
Placebo + intervention
BaselineYear 1BaselineYear 1
n17
21
IL-6 (pg/ml)2.13 (1.56–2.88)1.48 (1.18–2.04)*2.44 (1.62–3.20)1.37 (0.96–2.43)*
TNF-α (pg/ml)3.68 ± 1.002.64 ± 0.713.90 ± 1.223.05 ± 0.93*
C-reactive protein (mg/l)2.84 (1.16–6.28)2.03 (1.00–3.46)3.16 (1.43–5.50)1.97 (0.75–4.63)*
PAI-1 (ng/ml)51.4 (36.0–87.0)24.0 (10.4–33.2)*78.6 (46.4–113.3)54.0 (22.6–80.2)
Fibrinogen (mg/dl)247.5 ± 64.3342.6 ± 62.2254.7 ± 104.7332.0 ± 74.2*
  • Data are means ± SD or median (interquartile range 25th–75th percentile).

  • * P < 0.05,

  • P < 0.001 year 1 vs. baseline;

  • P < 0.05 placebo vs. orlistat.