Table 2

Follow-up time and medication adherence among patients with baseline uncontrolled A1C, BP, or LDL cholesterol, by intervention vs. control condition

Patients with uncontrolled A1CPatients with uncontrolled SBP (mm Hg)Patients with uncontrolled LDL cholesterol (mg/dL)
ControlInterventionP valueControlInterventionP valueControlInterventionP value
Follow-up ≥60 days533569403388315348
 Yes530 (99.4)563 (98.9)0.373395 (98.0)383 (98.7)0.445310 (98.4)344 (98.9)0.583
Follow-up ≥180 days533569403388n = 315n = 348
 Yes501 (94.0)529 (93.0)0.593365 (90.6)347 (89.4)0.646294 (93.3)327 (94.0)0.668
Drug coverage and follow-up ≥60 days533569403388315348
 Yes458 (85.9)481 (84.5)0.885317 (78.7)296 (76.3)0.445270 (85.7)299 (85.9)0.572
Drug coverage and follow-up ≥180 days533569403388315348
 Yes436 (81.8)456 (80.1)0.792295 (73.2)275 (70.9)0.590260 (82.5)289 (83.0)0.551
Primary adherence by the index date458481317296270299
 Yes348 (76.0)365 (75.9)0.932241 (76.0)234 (79.1)0.389189 (70.0)182 (60.9)0.023
Primary adherence within 60 days of  new prescription458481317296270299
 Yes401 (87.6)413 (85.9)0.540263 (83.0)254 (85.8)0.354221 (81.9)238 (79.6)0.474
Nonpersistence (<2 fills) at 180 days436456295275260289
 Yes165 (37.8)151 (33.1)0.141117 (39.7)99 (36.0)0.301134 (51.5)150 (51.9)0.725
MPR316341202214164174
 Mean ± SD0.793 ± 0.240.802 ± 0.220.9030.922 ± 0.1290.900 ± 0.1590.1260.846 ± 0.1780.851 ± 0.1840.839
 Median (minimum–maximum)0.912 (0.151–1.000)0.881 (0.215–1.000)1.000 (0.278–1.000)0.995 (0.188–1.000)0.909 (0.292–1.000)0.930 (0.175–1.000)
Change from baseline463506368363251288
 Mean ± SD−1.33 ± 1.87%
(−13 mmol/mol)−1.16 ± 1.80%
(−12 mmol/mol)0.149−16.4 ± 18.75−18.1 ± 20.560.255−33.0 ± 38.36−30.4 ± 39.020.438
 Median (minimum to maximum)−1.20% (−8.8 to 6.0%)−1.00% (−11.0 to 4.7%)−16.0 (−103 to 42)−17.0 (−82 to 57)−30.0 (−162 to 74)−28.5 (−175 to 110)
Decrease from baseline*463506368363251288
 Yes348 (75.2)373 (73.7)0.639279 (75.8)285 (78.5)0.380189 (75.3)218 (75.7)0.901
A1C change from baseline among late fillers9210368616698
 Mean ± SD−0.90 ± 1.85%
(−9 mmol/mol)−1.08 ± 1.78%
(−11 mmol/mol)0.476−15.6 ± 16.74−19.6 ± 21.600.248−22.3 ± 37.78−29.2 ± 35.530.227
 Median (minimum to maximum)−0.95% (−7.5 to 4.0%)
(−9 mmol/mol)−0.90% (−6.8 to 3.6%)
(−9 mmol/mol)−14.5 (−54 to 30)−17.5 (−68 to 25)−17.0 (−112 to 74)−29.0 (−108 to 110)
  • Data are n (%), unless otherwise specified.

  • *For A1C decrease form baseline of ≥0.2%.

  • †Late filler is patient with drug coverage who filled a new prescription after the index date.