Table 2—

Polymorphisms of candidate genes analyzed (n = 106)

GenePolymorphism
AdiponectinT94G*
C120T (arg112Cys in exon3)
G276T*
α estrogen receptorT938C*
α fibrinogenA4266G (Thr312Ala)*
AMP deaminaseC34T
Angiotensin II type 2 receptorA1166C
ACEI/D type*
AngiotensinogenT704C (Met235Thr)*
Apolipoprotein ET3932C (Cys112Arg)
T4070C (Arg158Cys)*
ATP binding cassette A1G1051A (Arg219Lys)*
ATP binding cassette C6C3421T
β2 adrenergic receptorA46G (Arg16Gly)*
C79G
C491T
β3 adrenergic receptorT190C (Trp64Arg)*
β fibrinogenC148T
Bradykinin B2 receptorC-58T*
C-C chemokine receptor 2G190A*
CD14T-159C*
CD18C1323T*
Cholesteryl ester transfer proteinG338A (Arg451Glu)
Connexin 37C1019T (Pro319Ser)*
C-reactive proteinG1059C
Dopamine-D2 receptorC3413G (Ser311Cys)
Early growth response factor-1C-151T
Ecto-nucleotide pyrophosphatase/phosphodiesterase 1C97A (Lys121Gln)
Endothelial nitric oxide synthaseT-786C
G894T (Glu298Asp)
Endothelin-1G5665T*
Epoxide hydrolaseCGT insertion after 1206 (Arg402–403ins)
G860A
E-selectionG98T
A561C (Ser128Arg
Factor VG1691A
Factor XIIC46T*
Fractalkine receptorG84635A (Val249Ile)
GhrelinC247A
GLUT enhancer-2A45474G
GLUT 1G283T*
Glutamate-cysteine ligaseC588T*
Glycogen synthaseA260G (Met416Val)
Glycoprotein IaA1648G
C807T*
Glycoprotein IIbIIIaC1565T
Gylcoprotein VIC13254C (Ser219Pro)
Hepatic lipaseC-480T*
Hemochromatosis (HFE)G4762C (His63Asp)
Human atrial natriuretic peptideT2238C
C708T
Human paraoxonaseA172T (Met 55Leu)
A584A (Gln192Arg)*
Human platelet alloantigen-2C1018T (Thr145Met)
Insulin receptor substrate-1G3494A (Gly971Arg)
Intercellular adhesion molecule-1G1548A (Glu469Lys)*
Interleukin-1αC-889T
Interleukin-1βC3953T
Interleukin-4 receptor αA398G (Ile50Val)
Interleukin-6C-634G
G-174C*
Interleukin-10G-1082A*
C-819T
Interleukin-13G4166A (Arg10Gln)
Interleukin-18C-607A*
G-137C
LDL receptor–related proteinC766T
Lipoprotein lipaseC3150G (Ser447 STOP)
Lymphotoxin αA252G*
Manganese superoxide dismutaseC1183T (Val16Ala)
Matrilysin promoterA-181G
Matrix Gla proteinG-7A*
Matrix metalloproteinase-7C-153T
Matrix metalloproteinase-9C-1562T*
Matrix metalloproteinase-12A-82G
Methionine synthaseA2756G (Asp919Gly)*
Methylenetetrahydrofolate reductaseC677T*
Microsomal triglyceride transfer proteinG-493T
Monocyte chemoattractant protein-1A-2518G
MyeloperoxidaseG-463A*
Neuropeptide YT1128C (Leu7Pro)
p22phoxC242T (His72Tyr)
Peroxisome proliferators–activated receptor αC696G (Leu162Val)
C892G (Pro12Ala)
Peroxisome proliferators–activated receptor α coactivator-1G1302A (Thr394Thr)*
G1564A (Gly482Ser)*
Plasminogen activator inhibitor-14G-668/5G*
PronatriodilatinC2238T
ProthrombinG20210A
P-selectinA37674C (Thr715Pro)
Receptor for advanced glycation end productsT-429C
A7221G (Gly82Ser)
Regulated upon activation, normal T-cell expressed and secreted (RANTUS)C-28G
Scavenger receptor class B type I (CLA-1)G4A (Gly2Ser)
G403A (Val135Ile)
Serotonin 2A receptorT102C*
ThrombomodulinG33A
ThrombopoietinA5713G*
Thrombospondin-1A2210G (Asn700Ser)
Thrombospondin-4G1186C (Ala387Pro)
Toll-like receptor 2C2029T
Transforming growth factor βT29C (Leu10Pro)*
TNF-αG-238A
G-308A
Vascular endothelial growth factorC-634G*
Von Willebrand factorG-1051A*
  • *

    * Common polymorphism in subjects with type 2 diabetes (minor allele frequency ≥10%);

  • polymorphism associated (P < 0.05) with an increase in IMT in the carotid artery.