Table 3—

Patient characteristics of subjects with or without the two combinations of SNPs

ACE DD and LTA 252 GG genotype
MTHFR 677 TT and LTA 252 GG genotype
Without (646)With (18)PWithout (644)With (18)P
n6461864418
Female/male315/3318/10NS312/3328/10NS
Age (years)62.6 ± 7.264.6 ± 15.2NS62.6 ± 7.166.3 ± 8.00.0286
Duration (years)12.5 ± 9.412.3 ± 9.3NS12.5 ± 9.414.0 ± 9.4NS
BMI (kg/m2)23.0 ± 3.222.7 ± 3.6NS23.0 ± 3.222.7 ± 3.2NS
A1C (%)7.3 ± 1.57.3 ± 1.0NS7.3 ± 1.57.1 ± 1.1NS
Total cholesterol (mg/dl)198 ± 36.5193 ± 33.4NS198 ± 37.1197 ± 40.2NS
Triglycerides (mg/dl)148 ± 115143 ± 108NS148 ± 115156 ± 99.0NS
HDL cholesterol (mg/dl)53.5 ± 16.454.5 ± 18.4NS53.9 ± 17.550.0 ± 12.8NS
Systolic blood pressure (mmHg)134 ± 14.9143 ± 15.20.01082134 ± 14.9137 ± 16.1NS
Diastolic blood pressure (mmHg)77.2 ± 8.482.9 ± 7.40.0045877.1 ± 8.382.1 ± 8.00.01114
Smoking habit (0/1)*514/13215/3NS513/131NSNS
Average IMT (mm)1.04 ± 0.341.43 ± 0.583.5 × 10−61.04 ± 0.341.54 ± 0.602.7 × 10−9
Previous myocardial infarction (no/yes)573/7312/60.01318569/7513/50.0883
  • Data are means ± SD. Student’s t test was used to compare continuous data between groups, and Pearson’s χ2 test to compare categorical data, sex, smoking habit, and previous myocardial infarction.

  • *

    * Smoking habit was evaluated as follows: value of 0 and 1 were assigned to subjects when the number of cigarettes per day × smoking years was <200 and ≥200, respectively. NS, not significant (P > 0.05).