Table 1—

Effect of glitazone therapy on established and emerging CVD risk factors (18)

CVD risk factorImpact of glitazone therapy
HyperglycemiaReduction in A1C
HypertensionReduction in blood pressure
DyslipidemiaReduction in triglycerides
Increase in HDL chlolesterol
Increase in LDL particle size (less atherogenic particles)
Markers of endothelial inflammationDecreased C-reactive protein
Decreased white blood cell count
Decreased fibrinogen
Decreased matrix metalloproteinases-9
Decreased tumor necrosis factor-α
Markers of elevated thrombotic riskDecreased plasminogen activator inhibitor-1
Decreased platelet aggregation