Characteristics of 346 patients with type 2 diabetes according to achievement of LDL cholesterol target <2.5 mmol/l, at baseline and over 18 months of follow-up
Characteristics | Baseline (cross-sectional data) | Over 18 months of follow-up | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Originally not at target (n = 216) | Originally at target (n = 130) | |||||||||||||||
Not at target (n = 216) | Already at target (n = 130) | Adjusted odds ratio (95% CI)* | Never at target (n = 195) | Achieved target (n = 21) | Adjusted odds ratio (95% CI)* | Maintains target (n = 47) | Lost target (n = 83) | Adjusted odds ratio (95% CI)* | ||||||||
Age >60 years | 62 | 50 | 1.8 (1.1–2.8) | 62 | 62 | — | 66 | 41 | 0.6 (0.4–0.9) | |||||||
Female | 60 | 52 | — | 62 | 38 | — | 43 | 59 | — | |||||||
High school or more | 28 | 39 | — | 22 | 40 | — | 23 | 48 | 2.4 (1.0–5.5) | |||||||
Income >$40,000/year | 24 | 27 | — | 22 | 40 | — | 17 | 33 | — | |||||||
Aboriginal | 26 | 24 | — | 24 | 19 | — | 28 | 26 | — | |||||||
Current smoker | 16 | 21 | — | 30 | 10 | — | 20 | 22 | — | |||||||
Median duration of diabetes (years) | 5 | 5 | — | 5 | 7 | — | 5 | 5 | — | |||||||
HbA1c (%) | 7.1 ± 1.4 | 7.4 ± 1.7 | — | 7.1 ± 1.4 | 7.4 ± 1.2 | — | 7.3 ± 1.7 | 7.4 ± 1.7 | — | |||||||
BMI >27 kg/m2 | 77 | 84 | — | 79 | 57 | — | 77 | 88 | — | |||||||
Systolic blood pressure (mmHg) | 132 ± 19 | 129 ± 17 | — | 131 ± 19 | 134 ± 20 | — | 129 ± 16 | 130 ± 17 | — | |||||||
Total cholesterol (mmol/l) | 5.4 ± 0.8 | 4.1 ± 1.0 | — | 5.4 ± 0.8 | 3.6 ± 0.3 | — | 3.5 ± 0.4 | 4.8 ± 0.5 | — | |||||||
LDL cholesterol (mmol/l) | 3.3 ± 0.6 | 2.0 ± 1.4 | — | 3.4 ± 0.5 | 2.3 ± 0.2 | — | 2.2 ± 0.3 | 3.0 ± 0.3 | — | |||||||
Lipid-lowering therapy | ||||||||||||||||
Taking | 14 | 24 | 2.1 (1.2–3.6) | 23 | 71 | — | 30 | 18 | — | |||||||
Started | NA | NA | NA | 13 | 57 | 9.2 (3.5–24.0) | 9 | 5 | — | |||||||
Stopped | NA | NA | NA | 2 | 0 | — | 4 | 4 | — |
Data are means ± SD or percent unless otherwise indicated.
↵* All odds ratios adjusted for intervention status (P > 0.5, all analyses, see text) and those variables presented in the table that were significant at P < 0.05 in the relevant multivariable model. NA, not applicable; — , not included in multivariable analyses.