Major topics and papers from the SEARCH study and ancillary studies*
| Burden of diabetes (prevalence/1,000) |
| 2001 (5); 2009 (6); changes in prevalence 2001–2009 (2); projections of diabetes burden to 2050 (50) |
| Risk of diabetes (incidence/100,000) |
| 2002 to 2003 (12); 2008 to 2009 (13); trends in incidence, non-Hispanic whites (2002–2009) (14) |
| Race/ethnicity–specific characteristics |
| Navajo (21); Asian, Pacific Islander (23); Hispanic (22); African American (24); non-Hispanic white (20) |
| Adiposity |
| Prevalence of overweight and obesity (25) |
| Weight-loss practices and weight-related issues (58) |
| Clinical, biochemical, and genetic findings |
| Glycemic control |
| Lipids and glycemic control (59) |
| Glycemic control and change in lipids (61) |
| Psychosocial burden and glycemic control (63) |
| HLA and genetics |
| HLA-associated phenotypes (60) |
| Time trends in HLA susceptibility among type 1 in Colorado (62) |
| Prevalence of MODY due to HNF1A, HNF4A, glucokinase (48), JDRF Monogenic Study* |
| Prevalence of permanent neonatal diabetes (64), JDRF Monogenic Study* |
| TCF7L2 and type 2 in multiethnic youth (66) |
| β-Cell function |
| Preservation of β-cell function in autoantibody positive youth (65) |
| Evolution of β-cell function (67) |
| Testing the accelerator hypothesis: body size, β-cell function, age at onset among type 1 (68) |
| Type of diabetes |
| Development of an insulin sensitivity score (46) |
| Etiologic approach to characterization of diabetes type (47) |
| CVD risk factors |
| CVD risk factor clustering (69) |
| Prevalence of elevated apoB and small, dense LDL (32) |
| Lipids among type 1 and control subjects (71), SEARCH CC* |
| CVD risk factors among type 2 and controls (73), SEARCH CC* |
| Prevalence of tobacco use and CVD risk factors (75) |
| Developmental origins |
| Maternal diabetes in utero and age at diagnosis among type 2 (70) |
| Maternal obesity and diabetes in utero and type 2 (72), SEARCH CC* |
| Breast-feeding and type 2 in three ethnic groups (74), SEARCH CC* |
| Behavioral factors |
| Physical activity and self-concept (76), SEARCH CC* |
| Physical activity and electronic media use (26), SEARCH CC* |
| TV and computer use (79) |
| Cardiovascular health among type 1 (81), SEARCH CVD* |
| Nutrition |
| Dietary intake (27) |
| Correlates of dietary intake (77) |
| DASH diet and CVD risk factors (78) |
| Change in DASH diet and CVD risk factors (80) |
| Sugar sweetened beverages and CVD risk profile (82) |
| DASH diet and hypertension (83) |
| Vitamin D insufficiency prevalence and association with insulin resistance (85), SNAS* |
| Nutritional factors and preservation of C-peptide among type 1 (87), SNAS* |
| Fructose intake and CVD risk factors among type 1 (89), SNAS* |
| Dietary intake patterns and arterial stiffness (91), SNAS* and CVD* |
| Quality of life |
| Health-related quality of life (84) |
| Demographic and clinical correlates of quality of life among type 1 (86) |
| Longitudinal associations among sex, self-care, and quality of life (88) |
| Prevalence and correlates of depressed mood (90) |
| Metabolic and inflammatory links with depression (92) |
| Acute complications |
| Prevalence of DKA at onset (19) |
| Trends in DKA at onset (44) |
| Risk factors and early complications |
| Carotid structure and function among type 1 (39), SEARCH CVD* |
| CVD risk factors associated with increased arterial stiffness among type 1 (93), SEARCH CVD* |
| Smoking and arterial stiffness among type 1 (95), SEARCH CVD* |
| Reduced HRV in type 1 and control subjects (36), SEARCH CVD* |
| Glycemic control and HRV (94), SEARCH CVD* |
| Reduced HRV is associated with increased arterial stiffness among type 1 (96), SEARCH CVD* |
| Quality of care |
| Barriers to care among type 1 (97) |
| Treatment patterns among type 2 (99) |
| Transition from childhood to adult care among type 1 (41) |
| Insulin regimens and clinical outcomes (42) |
| Predictors of insulin regimens among type 1 (102) |
| Spatial epidemiology and built environment |
| Neighborhood level risk factors among type 1 (98), SPATIAL* |
| Geographic variation in type 1 and 2 in four U.S. regions (100) |
| Surveillance |
| Ascertainment of diabetes using EHRs (54,101) |
| Adherence to treatment guidelines (40) |
Studies shown in Table 1 are not included in Table 2. CVD, cardiovascular disease; DASH, Dietary Approaches to Stop Hypertension; HRV, heart rate variability.
↵*Ancillary studies include SEARCH Case-Control (CC); SEARCH CVD; Juvenile Diabetes Research Foundation (JDRF) Monogenic Study; SEARCH Nutrition Ancillary Study (SNAS); and SEARCH Spatial Epidemiology of Diabetes (SPATIAL).