Table 4—

Meta-analysis of WMLs and lacunar infarcts

Imaging measureNo. of studiesSubjects
OR (95% CI)
Control (n)Diabetic (n)
    Vascular cohortsCT52,1296041.1 (0.9–1.4)
    Outpatient cohortsMRI: PVH21,024861.8 (0.9–3.6)
MRI: DWML21,024861.7 (0.9–3.5)
MRI: any WML24,0712462.4 (1.7–3.4)
Lacunar infarcts
    General cohortsMRI35,2817081.3 (1.1–1.6)
    Vascular cohortsCT51,3493382.3 (1.8–3.0)
MRI74,3898882.1 (1.8–2.5)
Total (CT + MRI)125,7381,2262.2 (1.9–2.5)
    Outpatient cohortsMRI43,9342911.4 (1.1–1.8)
  • Analyses were performed on the crude, unadjusted data. For WMLs, all studies that could be included in the meta-analysis are listed and marked with ‡ in the “Outcome and results” column in Table 1. The analysis on lacunar infarcts includes all studies listed in Table 2. any WML, studies that did not distinguish between DWML and PVH; DWML, deep WMLs; PVH, periventricular hyperintensities.