Table 1—

Clinical and biochemical characteristics of women with PCOS and normal control women

PCOS subjectsNormal subjectsP value (t test)
n2326
Age (years)31 (28–33)29 (26–31)0.30*
BMI (kg/m2)33.9 (29.9–38.5)25.6 (22.7–28.9)0.002
WHR0.81 (0.78–0.84)0.76 (0.73–0.78)0.006
Systolic blood pressure (mmHg)119 (113–125)109 (104–115)0.02
Diastolic blood pressure (mmHg)70 (66–73)64 (61–67)0.03
Total testosterone (ng/dl)71 (58–87)39 (32–47)<0.001*
Free testosterone calculation (ng/dl)0.79 (0.59–1.06)0.24 (0.19–0.32)<0.001
Fasting insulin (μIU/ml)4.9 (3.5–6.8)3.0 (2.2–4.1)0.047*
AUCinsulin (μIU · min−1 · ml−1)5,479 (4,206–7,140)2,312 (1,803–2,965)<0.001§
Si (by FSIVGTT)2.3 (1.4–3.8)12.5 (7.7–20.2)<0.001§
Plasma DCI (μmol/l)0.10 (0.07–0.16)0.19 (0.13–0.28)0.035
24-h urinary DCI (μmol/day)2.3 (1.1–4.9)0.7 (0.4–1.5)0.043*
Urinary clearance of DCI (ml/min)15.3 (7.7–30.5)2.7 (1.4–5.1)0.001*§
Plasma MYO (μmol/l)20.6 (18.8–22.4)21.2 (19.5–23.0)0.62
24-h urinary MYO (μmol/day)98 (66–144)65 (45–94)0.13
Urinary clearance of MYO (ml/min)3.4 (2.3–4.9)2.2 (1.5–3.1)0.10
AUCDCI-IPG (%/min)12,492 (11,212–13,919)14,820 (13,386–16,408)0.025
AUCDCI-IPG/AUCinsulin2.3 (1.7–3.0)6.4 (4.9–8.4)<0.001§
  • Data are means (95% CIs) unless otherwise indicated. To convert values for total testosterone to nanomoles per liter, multiply by 0.0347; to convert values for free testosterone to picomoles per liter, multiply by 34.7; and to convert values for insulin to picomoles per liter, multiply by 6.9. Note that only significant partial P values (‡, §, or ‖) after correction for BMI and/or Si are reported (multiple linear regression analyses). FSIVGGT, frequently sampled intravenous glucose tolerance test.

  • *

    * Unequal variance t test.

  • Geometric means.

  • P < 0.05 when corrected for BMI and Si.

  • §

    § P < 0.05 when corrected for BMI.

  • P < 0.05 when corrected for Si.