Table 1—

Contrasting and overlapping actions of GLP-1R and amylin agonists and DPP-IV inhibitors

Amylin agonistsGLP-1R agonistsDPP-IV inhibitors
Enhance insulin secretion++
Inhibit glucagon secretion+++
Slow gastric emptying++
Induce satiety and weight loss++
Improve β-cell function++