Table 1—

Slopes (per month) of glucose (mg/dl) and C-peptide (ng/ml) indexes from OGTTs at visits from 30 to 6 months before diagnosis

Parenteral
Oral
InsulinNo insulinInsulinNo insulin
n11111913
Fasting glucose0.35 ± 0.37*0.41 ± 0.51*0.47 ± 0.470.27 ± 0.62
2-h glucose2.68 ± 2.541.43 ± 2.251.92 ± 1.632.31 ± 1.86
AUC glucose168 ± 10699 ± 157204 ± 192181 ± 138
Fasting C-peptide−0.00 ± 0.04−0.00 ± 0.020.01 ± 0.02*−0.01 ± 0.04
Peak C-peptide−0.03 ± 0.06−0.00 ± 0.04−0.01 ± 0.06−0.04 ± 0.07
AUC C-Peptide−2.50 ± 7.570.02 ± 4.04−2.07 ± 5.51−4.16 ± 7.30
Fasting C-peptide–to–glucose ratio (×103)−0.1 ± 0.4−0.1 ± 0.30.1 ± 0.3−0.2 ± 0.3
Peak C-peptide–to–2-h glucose ratio (×103)−0.6 ± 0.5−0.4 ± 0.6−0.7 ± 0.9−0.7 ± 0.8
AUC C-peptide–to–glucose ratio (×103)−0.3 ± 0.4*−0.1 ± 0.2−0.4 ± 0.4−0.4 ± 0.4
  • Data are means ± SD. P values are for differences from 0.

  • * P < 0.05;

  • P < 0.01;

  • P < 0.001.