Table 2—

Cumulative 30-day mortality and adjusted 30-day MRRs for patients with peptic ulcer bleeding and perforation, according to the presence of diabetes

Peptic ulcer bleeding
Peptic ulcer perforation
n30-day mortality (%)Adjusted 30-day MRR (95% CI)*P value (for adjusted 30-day MRR)n30-day mortality (%)Adjusted 30-day MRR (95% CI)*P value (for adjusted 30-day MRR)
Unstratified
    No diabetes6,50110.11.0 (reference)1,92124.01.0 (reference)
    Diabetes present73116.61.40 (1.15–1.70)<0.00114042.91.51 (1.15–1.98)0.003
Stratified by heart disease
    No heart disease
No diabetes5,5529.51.0 (reference)1,71221.91.0 (reference)
Diabetes present50813.81.28 (0.99–1.64)0.069935.41.41 (0.99–2.01)0.05
    Heart disease present
No diabetes97613.51.11 (0.91–1.34)0.3220941.21.37 (1.08–1.74)0.01
Diabetes present22322.91.86 (1.39–2.49)<0.0014161.02.29 (1.51–3.46)<0.001
Stratified by renal disease
    No renal disease
No diabetes6,3179.91.0 (reference)1,89523.81.0 (reference)
Diabetes present69216.01.39 (1.13–1.70)0.00213242.41.55 (1.17–2.05)0.003
    Renal disease present
No diabetes18415.21.42 (0.97–2.07)0.072638.51.48 (0.79–2.80)0.22
Diabetes present3925.62.46 (1.31–4.62)0.005850.01.40 (0.52–3.78)0.51
  • Unstratified estimates and values stratified for the presence of heart and renal disease. Heart disease = previous discharge diagnoses of acute myocardial infarction and/or congestive heart failure as evidenced in the Charlson Index; renal disease = previous discharge diagnoses of moderate to severe renal disease as evidenced in the Charlson Index.

  • *

    * Adjusted for sex, age, Charlson Index score level, previous uncomplicated peptic ulcer disease, use of antiulcer drugs, and use of drugs associated with peptic ulcer complications. Heart and renal disease were excluded from the Charlson Index when stratified by this variable.