Table 1—

Prevalence of diabetes among people with HCV infection in comparison with other liver diseases not HCV, taking into account the degree of liver damage (chronic hepatitis or cirrhosis)

Chronic hepatitis
HCV infection (n)Prevalence of diabetesOther liver diseases not HCV (n)Prevalence of diabetesP
Özylilkan et al. (42)8625.5114 HCV (−)7.80.001
Mangia et al. (43)*1024.922 HBV, 14 OH0 0NS
Mason et al. (19)21218.4144 HBV9.70.02
Knobler et al. (28)*453388 HBV120.004
Ryu et al. (21)§6823.5157 HBV8.20.002
Lecube et al. (39)*3801792 HCV (−)70.03
Cirrhosis
HCV infection (n)Prevalence of diabetesOther liver diseases not HCV (n)Prevalence of diabetesP
Allison et al. (44)#345066 HCV (−)9<0.0001
Özylilkan et al. (42)5038.0133 HCV (−)12.00.00006
del Olmo et al. (45)**11223.375 OH, 51 HBV25.3, 27.5NS, NS
Mangia et al. (43)*15734.338 HBV, 49 OH31.5, 28.5NS, NS
Guerrero et al (46)#2828.647 HCV (−)10.6<0.05
Mason et al. (19)14533.188 HBV20.50.04
Caronia et al. (47)**115123.6181 HBV9.40.0002
Zein et al. (37)642578 CLD, 53 OH1.3, 190.0001, NS
Bigam et al. (48)*1102953 HBV, 115 CLD6, 4<0.001, <0.001
Ryu et al. (21)2825102 HBV, 43 OH13.7, 30.2NS, NS
Garrido et al. (49)*#503650 HCV (−)18<0.05
Thuluvath et al. (32)*#9719.6194 HCV (−)11.5NS
Parolin et al. (50)3636.1170 HCV (−)25.71NS
Lecube et al. (39)*1184052 HCV (−)36NS
  • Data are percent, unless otherwise indicated. Diagnosis of type 2 diabetes according to

  • ‖fasting plasma glucose >216 mg/dl,

  • *

    * fasting plasma glucose >126 mg/dl,

  • fasting plasma glucose >140 mg/dl;

  • **

    ** treatment with hypoglycemic agents or insulin. Diagnosis of liver damage according to

  • liver biopsy,

  • §

    § not specified,

  • end-stage liver disease in pretransplant situation.

  • #

    # Both groups equipared by age, sex, and Child-Pugh degree. CLD, cholostatic liver disease; HBV, chronic HBV infection; OH, alcohol hepatic disease.