Table 1—

Summary of insulin titration algorithm used for both insulins

Criteria for titrationInsulin dose adjustment (units or IU)
RespondersNonresponders
If average prebreakfast/predinner plasma glucose:
    >10.0 mmol/l (>180 mg/dl)+10+10
    9.1–10.0 mmol/l (163–180 mg/dl)+6+8
    8.1–9.0 mmol/l (145–162 mg/dl)+4+6
    7.1–8.0 mmol/l (127–144 mg/dl)+2+4
    6.1–7.0 mmol/l (109–126 mg/dl)+2+2
If one prebreakfast plasma glucose:
    3.1–4.0 mmol/l (56–72 mg/dl)−2
    <3.1 mmol/l (<56 mg/dl)−4
  • Plasma glucose categories are based on the average of three consecutive self-measurements immediately preceding each contact. Responders: people in whom the average plasma glucose value was reduced to a lower category following the previous adjustment. Nonresponders: people in whom the average plasma glucose value remained in the same category or increased following the last adjustment.