Table 1—

Physical characteristics of the subject groups at baseline and following 6 months of calorie restriction

nControl (n = 11)
CR (n = 12)
CREX (n = 12)
LCD (n = 11)

BaselineMonth 6BaselineMonth 6BaselineMonth 6BaselineMonth 6P*
Body composition
    Weight (kg)81.8 ± 2.881.9 ± 2.881.0 ± 3.372.6 ± 3.182.0 ± 3.073.9 ± 2.881.0 ± 3.370.0 ± 3.0†<0.0001
    Body (kg)31.3 ± 1.830.9 ± 2.131.0 ± 2.426.6 ± 2.432.6 ± 2.227.6 ± 2.433.0 ± 2.426.5 ± 2.7<0.0001
    Fat mass (kg)25.5 ± 1.225.0 ± 1.724.9 ± 1.819.1 ± 1.726.4 ± 1.720.1 ± 1.726.5 ± 1.918.4 ± 1.9<0.0001
    Fat-free mass (kg)56.8 ± 3.156.5 ± 3.156.3 ± 3.553.7 ± 3.355.6 ± 3.553.6 ± 3.254.6 ± 3.451.5 ± 3.3<0.0001
Fat distribution
    VAT (kg)2.9 ± 0.42.8 ± 0.43.2 ± 0.52.3 ± 0.42.8 ± 0.42.0 ± 0.42.9 ± 0.51.8 ± 0.3<0.0001
    SAT (kg)7.7 ± 0.67.8 ± 0.77.8 ± 0.75.8 ± 0.68.2 ± 0.86.0 ± 0.88.2 ± 0.85.6 ± 0.7<0.0001
    DSAT (kg)3.6 ± 0.33.6 ± 0.33.8 ± 0.32.7 ± 0.33.8 ± 0.42.7 ± 0.43.9 ± 0.42.5 ± 0.3<0.0001
    Fat cell size (μl)0.73 ± 0.050.72 ± 0.040.65 ± 0.050.51 ± 0.020.70 ± 0.040.52 ± 0.060.67 ± 0.060.51 ± 0.05<0.001
    IHL (% of oil phantom)1.60 ± 0.392.36 ± 0.811.66 ± 0.560.69 ± 0.131.17 ± 0.210.65 ± 0.101.16 ± 0.290.55 ± 0.09<0.003
    IMCL (%of oil phantom)4.05 ± 0.504.20 ± 0.923.79 ± 0.333.54 ± 0.432.88 ± 0.262.84 ± 0.294.00 ± 0.863.33 ± 0.70NS
Insulin sensitivity
    Fasting glucose (mg/dl)90.2 ± 1.291.8 ± 2.189.3 ± 1.888.0 ± 2.392.0 ± 1.891.8 ± 2.089.1 ± 0.889.7 ± 1.0NS
    Fasting insulin (μU/ml)12.4 ± 1.013.0 ± 1.89.4 ± 1.56.6 ± 0.99.8 ± 1.07.0 ± 0.711.0 ± 0.99.4 ± 1.3<0.05
    Si (10−4 mU · l−1 · min−1)2.8 ± 0.42.5 ± 0.43.3 ± 0.54.2 ± 1.03.4 ± 0.45.3 ± 0.83.1 ± 0.64.7 ± 0.90.09
    AIRg (mU · l−1 · min−1)750 ± 135685 ± 98815 ± 136558 ± 71729 ± 175440 ± 115892 ± 231587 ± 1610.09
  • Data are means ± SE.

  • *

    * Differences between treatment groups for the change scores using an ANCOVA with the absolute change as the dependent variable and the baseline score as a covariate.

  • Significant change from baseline.