Clinical and metabolic parameters of 50 MICU patients according to the insulin regimen used
| Insulin regimen | Intravenous | Subcutaneous | Statistics |
|---|---|---|---|
| Baseline characteristics | |||
| Men/women | 13/9 | 18/10 | NS |
| Age (years) | 60 ± 13 | 63 ± 18 | NS |
| BMI (kg/m2) | 27.5 ± 7.1 | 25.9 ± 7.3 | NS |
| Diabetes (no/type 2/type 1) | 9/9/4 | 21/7/0 | 0.021 |
| APACHE II score | 27 ± 7 | 19 ± 6 | <0.0001 |
| SOFA score (at start) | 9 ± 4 | 7 ± 4 | 0.014 |
| Primary condition | |||
| Septic shock | 13 | 4 | 0.002 |
| Cardiogenic shock | 3 | 3 | NS |
| Respiratory failure | 1 | 9 | 0.029 |
| Neurologic event | 0 | 4 | NS |
| Cardiopulmonary resuscitation | 1 | 4 | NS |
| Clinical outcome | |||
| Mortality | 7 | 8 | NS |
| Corticosteroid therapy | 12 | 3 | 0.001 |
| Vasopressor therapy | 14 | 10 | NS |
| Enteral nutrition | 3 | 11 | 0.061 |
| Parenteral nutrition | 10 | 1 | 0.001 |
| Renal failure (CVVH or HD) | 9 | 2 | 0.006 |
| Mechanical ventilation | 16 | 17 | NS |
| Metabolic outcome | |||
| Insulin dose (day 1) (units/day) | 141 ± 100 | 15 ± 26 | <0.0001 |
| Insulin dose (day 2) (units/day) | 125 ± 99 | 19 ± 31 | <0.0001 |
| Mean glycaemia (mg/dl) | 141 ± 56 | 149 ± 61 | NS |
| % time at glycemia | |||
| <60 mg/dl | 6 ± 9 | 4 ± 11 | NS |
| 80–110 mg/dl | 26 ± 21 | 19 ± 22 | NS |
| >110 mg/dl | 55 ± 22 | 71 ± 24 | 0.016 |
| >140 mg/dl | 35 ± 24 | 42 ± 29 | NS |
| >200 mg/dl | 13 ± 19 | 16 ± 23 | NS |
Data are means ± SD or number (n). CVVH, continuous venovenous hemofiltration; HD, hemodialysis.