Table 1—

Clinical and metabolic parameters of 50 MICU patients according to the insulin regimen used

Insulin regimenIntravenousSubcutaneousStatistics
Baseline characteristics
    Men/women13/918/10NS
    Age (years)60 ± 1363 ± 18NS
    BMI (kg/m2)27.5 ± 7.125.9 ± 7.3NS
    Diabetes (no/type 2/type 1)9/9/421/7/00.021
    APACHE II score27 ± 719 ± 6<0.0001
    SOFA score (at start)9 ± 47 ± 40.014
Primary condition
    Septic shock1340.002
    Cardiogenic shock33NS
    Respiratory failure190.029
    Neurologic event04NS
    Cardiopulmonary resuscitation14NS
Clinical outcome
    Mortality78NS
    Corticosteroid therapy1230.001
    Vasopressor therapy1410NS
    Enteral nutrition3110.061
    Parenteral nutrition1010.001
    Renal failure (CVVH or HD)920.006
    Mechanical ventilation1617NS
Metabolic outcome
    Insulin dose (day 1) (units/day)141 ± 10015 ± 26<0.0001
    Insulin dose (day 2) (units/day)125 ± 9919 ± 31<0.0001
    Mean glycaemia (mg/dl)141 ± 56149 ± 61NS
    % time at glycemia
        <60 mg/dl6 ± 94 ± 11NS
        80–110 mg/dl26 ± 2119 ± 22NS
        >110 mg/dl55 ± 2271 ± 240.016
        >140 mg/dl35 ± 2442 ± 29NS
        >200 mg/dl13 ± 1916 ± 23NS
  • Data are means ± SD or number (n). CVVH, continuous venovenous hemofiltration; HD, hemodialysis.