Table 3

Sensitivity analyses for risk for all-cause mortality (HR [95% CI]) according to categories of glycemic status

Prediabetes
Normoglycemia HbA1c <5.7% (<39 mmol/mol)High diabetes risk HbA1c 5.7–5.9% (39–41 mmol/mol)Very high diabetes risk HbA1c 6.0–6.4% (42–46 mmol/mol)Undiagnosed diabetes HbA1c ≥6.5% (≥48 mmol/mol)Known diabetes
Exclusions of people with
 <2 years of follow-up (n = 52)*1.001.06 (0.82–1.36)0.84 (0.64–1.11)1.59 (1.18–2.16)1.41 (1.06–1.86)
 History of myocardial infarction, stroke, or cancer (n = 393)1.001.07 (0.82–1.40)0.89 (0.66–1.20)1.78 (1.29–2.47)1.37 (0.99–1.89)
 Baseline conditions known to affect HbA1c (n = 444)*1.001.04 (0.80–1.36)0.89 (0.66–1.20)1.73 (1.26–2.37)1.58 (1.18–2.13)
HbA1c <5.0% (<31 mmol/mol)HbA1c 5.0 to <5.7% (31 to <39 mmol/mol)
Reference set at HbA1c 5.0 to <5.7% (31 to <39 mmol/mol)*1.70 (1.16–2.50)1.001.09 (0.85–1.39)0.92 (0.71–1.20)1.72 (1.29–2.30)1.49 (1.14–1.96)
  • Number (%) of deceased for HbA1c <5.0% (<31 mmol/mol): 32 (3.7%); for HbA1c 5.0 to <5.7% (31 to <39 mmol/mol): 163 (5.2%).

  • *Model is adjusted for the same variables as model 3 of Table 2.

  • †Model is adjusted for the same variables as model 3 of Table 2 except for history of myocardial infarction, stroke, and cancer at baseline.

  • ‡Baseline conditions known to affect HbA1c were pregnancy, anemia, chronic kidney disease, hepatitis, or chronic liver disease.