Table 1—

CHD risk prediction equations: UKPDS Risk Engine and Framingham functions

UKPDS Risk Engine (12)
−q = 0.0112 × 1.059(age − 55) × 0.525(sex) × 0.390(race) × 1.35(smoker) × 1.183(A1C) × 1.088(SBP − 135.7/10) × 3.845 [(ln total cholesterol/HDL cholesterol)]
    Calculation of risk
        −R(t) = 1 − exp {−q(1−dt)/1−day}
Framingham functions (44)
    Men: X1 = 11.1122 − 1.4792 × log(age) − 0.9119 × log(SBP) − 0.7181 × log(total cholesterol/HDL cholesterol) − 0.2767 × smoking − 0.1759 × diabetes − 0.5865 × left ventricular hypertrophy
    Women: X1 = 5.2573 + 1.8515 × [log(age/74)]2 − 0.9119 × log(SBP) − 0.7181 × log(total cholesterol/HDL cholesterol) − 0.2767 × smoking − 0.3785 × diabetes − 0.5865 × left ventricular hypertrophy
    For both men and women: X2 = [−2.1155149 − X1]/exp(−0.3155 − 0.2784 × X1)
        Probability for CHD within 10 years = 100 × (1 − exp [−exp(X2)])
  • SBP, systolic blood pressure.