Table 1—

Efficacy parameters in patients receiving vildagliptin (100 mg daily)

All
Aged <65 years
Aged ≥65 years
BLAMΔBLAMΔBLAMΔ
n1,4691,231238
A1C (%)8.6 ± 0.0−1.0 ± 0.0*8.7 ± 0.0−1.0 ± 0.0*8.3 ± 0.1−1.2 ± 0.1*
FPG (mmol/l)10.4 ± 0.1−1.1 ± 0.1*10.5 ± 0.1−1.1 ± 0.1*9.6 ± 0.1−1.5 ± 0.2*
Body weight (kg)90.6 ± 0.5−0.3 ± 0.192.0 ± 0.6−0.2 ± 0.183.4 ± 1.0−0.9 ± 0.3*
Responder analyses (achieving A1C <7.0%)nn (%) respondersnn (%) respondersnn (%) responders
Overall1,462548 (37.5)1,226438 (35.7)236110 (44.6)
Baseline A1C ≤8.0%526286 (54.4)405210 (51.9)12176 (62.8)
Fasting lipids (mmol/l)AM%ΔAM%ΔAM%Δ
    Triglycerides2.4 ± 0.1−3.3 ± 1.3*2.4 ± 0.1−2.8 ± 1.4*2.1 ± 0.1−6.3 ± 2.9*
    Total cholesterol5.3 ± 0.0−2.2 ± 0.4*5.3 ± 0.0−2.0 ± 0.5*5.3 ± 0.1−3.0 ± 1.0*
    LDL3.1 ± 0.0−0.7 ± 0.83.1 ± 0.0−0.3 ± 0.83.1 ± 0.1−2.5 ± 1.7
    HDL1.2 ± 0.04.5 ± 0.6*1.1 ± 0.04.5 ± 0.6*1.3 ± 0.04.8 ± 1.3*
    Non-HDL4.1 ± 0.0−3.3 ± 0.6*4.2 ± 0.0−3.0 ± 0.6*4.0 ± 0.1−4.9 ± 1.3*
    VLDL0.95 ± 0.01−3.4 ± 1.1*1.0 ± 0.0−3.0 ± 1.3*0.9 ± 0.0−5.3 ± 2.4*
Blood pressure (mmHg)mean Δmean Δmean Δ
    Diastolic81.3 ± 0.3−1.4 ± 0.2*81.5 ± 0.2−1.3 ± 0.2*80.1 ± 0.5−2.0 ± 0.5*
    Systolic132.1 ± 0.3−2.2 ± 0.3*130.8 ± 0.4−2.2 ± 0.4*138.5 ± 0.8−2.2 ± 1.0*
Subgroup analysesBL (n)AMΔBL (n)AMΔBL (n)AMΔ
    A1C (%)
BL A1C ≤8.0%7.6 (533)−0.6 ± 0.0*7.6 (410)−0.6 ± 0.1*7.6 (123)−0.7 ± 0.1*
BL A1C >8.0%9.2 (936)−1.3 ± 0.1*9.2 (821)−1.2 ± 0.1*9.0 (115)−1.4 ± 0.1*
BL A1C ≤9.0%8.1 (995)−0.8 ± 0.0*8.1 (806)−0.7 ± 0.0*7.9 (189)−0.9 ± 0.1*
BL A1C >9.0%9.9 (474)−1.6 ± 0.1*9.9 (425)−1.6 ± 0.1*9.7 (49)−1.7 ± 0.2*
BL BMI <30 kg/m28.7 (613)−1.2 ± 0.1*8.8 (487)−1.2 ± 0.1*8.4 (126)−1.3 ± 0.1*
BL BMI ≥30 kg/m28.6 (855)−0.9 ± 0.1*8.7 (743)−0.9 ± 0.1*8.2 (112)−1.0 ± 0.1*
BL BMI <35 kg/m28.7 (1,034)−1.1 ± 0.0*8.8 (838)−1.1 ± 0.1*8.3 (196)−1.2 ± 0.1*
BL BMI ≥35 kg/m28.6 (434)−0.9 ± 0.1*8.6 (392)−0.9 ± 0.1*8.2 (42)−0.9 ± 0.2*
    Body weight (kg)
BL BMI <30 kg/m275.6 (613)−0.0 ± 0.175.8 (487)0.1 ± 0.174.5 (126)−0.5 ± 0.3
BL BMI ≥30 kg/m2101.3 (855)−0.6 ± 0.2*102.6 (743)−0.5 ± 0.2*93.3 (112)−1.3 ± 0.4*
BL BMI <35 kg/m282.1 (1,034)−0.2 ± 0.182.8 (838)−0.1 ± 0.179.4 (196)−0.8 ± 0.2*
BL BMI ≥35 kg/m2110.7 (434)−0.6 ± 0.3*111.7 (392)−0.6 ± 0.3*101.8 (42)−1.4 ± 0.7*
  • Data are means ± SE unless otherwise indicated.

  • *

    * P < 0.05 vs. baseline (within group);

  • P < 0.05 vs. younger subgroup.

  • Patients with both baseline A1C ≥7% and an end point value. BL, baseline.