Table 1—

Baseline characteristics of the original DIAD-1 cohort and patients with (DIAD-2) and without repeat adenosine 99mTc-sestamibi SPECT imaging

Original adenosine SPECT (DIAD-1)Repeat adenosine SPECT (DIAD-2)No repeat adenosine SPECTP
n522358164
Demographics
    Age (years)60.7 ± 6.860.6 ± 6.760.9 ± 6.90.67
    Sex
        Male277 (53)196 (56)81 (49)
        Female245 (47)162 (44)83 (51)0.25
    Race
        White419 (80)305 (85)114 (70)
        Black79 (15)36 (10)43 (26)
        Other24 (5)17 (5)7 (4)<0.0001
BMI (kg/m2)31.1 ± 6.631.0 ± 6.431.1 ± 6.90.99
Diabetes duration (years)8.2 ± 7.18.0 ± 7.08.6 ± 7.30.36
A1C (%)7.1 ± 1.57.0 ± 1.47.4 ± 1.70.005
Treatment
    Insulin52 (10)35 (10)17 (10)
    Insulin + oral agent67 (12)46 (13)21 (13)
    Diet only77 (15)64 (18)13 (8)
    Oral agent326 (63)213 (59)113 (69)0.04
    Metformin286 (55)190 (53)96 (59)0.24
    Sulfonylurea207 (40)126 (35)81 (49)0.002
    Thiazolidinedione106 (20)75 (21)31 (19)0.59
Peripheral neuropathy symptoms/signs
    Numbness163 (31)101 (28)62 (38)0.03
    Pain51 (10)32 (9)19 (12)0.34
    Tingling141 (27)92 (26)49 (30)0.32
    Absent vibration145 (28)90 (25)55 (34)0.05
    Absent sensation59 (11)36 (10)23 (14)0.18
    Absent reflex161 (31)116 (32)45 (27)0.25
Autonomic neuropathy symptoms
    Bloating85 (16)55 (15)30 (18)0.40
    Dizziness89 (17)54 (15)35 (21)0.08
    Erectile dysfunction134 (48)87 (44)81 (58)0.03
    Abnormal Valsalva ratio99 (19)60 (17)39 (24)0.06
    Peripheral vascular disease47 (9)29 (8)18 (11)0.29
Smoking
    Never/past471 (90)327 (91)144 (88)
    Current51 (10)31 (9)20 (12)0.33
Lipid treatment242 (47)169 (47)73 (45)0.57
LDL (mg/dl)113 ± 32114 ± 31111 ± 340.36
Triglycerides (mg/dl)170 ± 118169 ± 115173 ± 1250.74
Hypertension treatment291 (56)193 (54)98 (60)0.21
Systolic blood pressure (mmHg)131 ± 17132 ± 17131 ± 170.57
Diastolic blood pressure (mmHg)79 ± 879 ± 978 ± 80.16
Aspirin use229 (44)151 (42)78 (48)0.25
Family history CAD110 (21)70 (20)40 (24)0.21
Retinopathy73 (14)41 (11)32 (20)<0.0001
Albuminuria112 (22)70 (20)42 (26)0.10
Adenosine 99mTc SPECT imaging results (DIAD-1)
    Normal409 (78)287 (80)122 (74)0.12
    Abnormal113 (22)71 (20)42 (26)
        Perfusion abnormalities83 (16)54 (15)29 (17)
            Small defects50 (10)38 (11)12 (7)
            Moderate/large defects33 (6)16 (4)17 (10)
        Nonperfusion abnormalities30 (6)17 (5)13 (9)
            Abnormal ECG21 (4)11 (3)10 (7)
            Transient ischemic dilation4 (1)4 (1)0 (0)
            Left ventricular dysfunction5 (1)2 (1)3 (2)
  • Data are means ± SD or n (%).