Table 3—

Effects of DHEA treatment on DHEA, DHEAS, oxidative and antioxidant parameters, and TNF-α/TNF-α receptor system in plasma and/or PBMCs

DHEA (50 mg/die)
Plasma
PBMCs
Baseline12 weeksPBaseline12 weeksP
ROS (UF/ml)372.3 ± 66.6183.0 ± 12.1<0.05307.4 ± 40.7186.7 ± 37.1<0.01
HNE (μmol/l)6.40 ± 0.813.17 ± 0.42<0.0015.09 ± 0.272.60 ± 0.41<0.001
GSH (μg/ml)60.7 ± 2.085.7 ± 2.4<0.01314.4 ± 53.7534.1 ± 73.8<0.01
DHEA (nmol/l)24.5 ± 2.732.8 ± 2.8<0.05NDND
DHEAS (μmol/l)1.7 ± 0.22.2 ± 0.1<0.05NDND
Vitamin E (μmol/l)68.3 ± 5.4120.3 ± 10.9<0.01NDND
Pentosidine (μmol/l)2.31 ± 0.131.31 ± 0.06<0.001NDND
TNF-α (pg/ml)3.10 ± 1.406.88 ± 1.62NSNDND
TNF-RI (pg/ml)1602 ± 1151591 ± 112NSNDND
TNF-RII (pg/ml)3,440 ± 3652,829 ± 471<0.01NDND
  • Data are means ± SE, n = 10. Statistical analysis was performed using the paired data Student's t test.