Table 3—

Lipoprotein kinetics in the subjects before and after weight reduction and weight maintenance

Weight reduction (n = 20)
Weight maintenance (n = 15)
016 weeks016 weeks
VLDL apoB
    Pool size (mg)358 ± 57218 ± 28*287 ± 66318 ± 48
    Concentration (mg/l)106 ± 1956 ± 6*86 ± 1896 ± 14
    Fractional catabolic rate (pools/day)4.26 ± 0.794.61 ± 0.738.05 ± 2.575.11 ± 0.92
    Production rate (mg · kg FFM−1 · day−1)23.8 ± 3.0115.6 ± 1.63*30.0 ± 4.6528.1 ± 3.92
LDL apoB
    Pool size (mg)1,347 ± 1271,038 ± 891,217 ± 1161,270 ± 110
    Concentration (mg/l)390 ± 33296 ± 24348 ± 38385 ± 29
    Fractional catabolic rate (pools/day)0.51 ± 0.050.65 ± 0.060.63 ± 0.070.51 ± 0.05
    Production rate (mg · kg FFM−1 · day−1)14.1 ± 1.9012.1 ± 1.1716.5 ± 1.4915.6 ± 2.17
HDL apoA-I
    Pool size (mg)4,394 ± 2104,427 ± 2044,038 ± 1473,929 ± 165
    Concentration (mg/l)1,290 ± 461,256 ± 441,199 ± 351,228 ± 25
    Fractional catabolic rate (pools/day)0.23 ± 0.010.20 ± 0.010.25 ± 0.010.24 ± 0.01
    Production rate (mg · kg FFM−1 · day−1)15.1 ± 1.1213.1 ± 0.9715.5 ± 1.0115.1 ± 1.13
Lipoprotein channeling
    % of total67.7 ± 6.883.5 ± 5.5*70.5 ± 8.364.4 ± 7.8
    % of direct12.2 ± 3.519.4 ± 5.210.1 ± 2.114.6 ± 2.6
    % via IDL55.5 ± 6.964.2 ± 5.660.4 ± 8.249.8 ± 7.6
  • Data are means ± SEM.

  • *

    * Significant differences in the weight loss group relative to weight maintenance group were analyzed using general linear modeling: P < 0.01;

  • Significant differences in the weight loss group relative to weight maintenance group were analyzed using general linear modeling: P < 0.05;

  • Significant differences in the weight loss group relative to weight maintenance group were analyzed using general linear modeling: P = 0.06.